Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma

Tubercular granulomas are a common manifestation of intraocular tuberculosis. These are said to be hypoxic granulomas with increased expression of vascular endothelial growth factor (VEGF). Management of these granulomas includes a combination of antitubercular therapy (ATT) and oral corticosteroids...

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Autores principales: Agarwal, Manisha, Gupta, Chanda, Mohan, K Varsha, Upadhyay, Pramod K, Jha, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690512/
https://www.ncbi.nlm.nih.gov/pubmed/32823472
http://dx.doi.org/10.4103/ijo.IJO_1261_20
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author Agarwal, Manisha
Gupta, Chanda
Mohan, K Varsha
Upadhyay, Pramod K
Jha, Vivek
author_facet Agarwal, Manisha
Gupta, Chanda
Mohan, K Varsha
Upadhyay, Pramod K
Jha, Vivek
author_sort Agarwal, Manisha
collection PubMed
description Tubercular granulomas are a common manifestation of intraocular tuberculosis. These are said to be hypoxic granulomas with increased expression of vascular endothelial growth factor (VEGF). Management of these granulomas includes a combination of antitubercular therapy (ATT) and oral corticosteroids. We report a case of tubercular granuloma with exudative retinal detachment which was treated with weekly intravitreal anti-VEGF and antibiotic injections along with ATT and corticosteroids. The VEGF levels measured paralleled with the clinical regression of the granuloma.
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spelling pubmed-76905122020-12-30 Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma Agarwal, Manisha Gupta, Chanda Mohan, K Varsha Upadhyay, Pramod K Jha, Vivek Indian J Ophthalmol Case Reports Tubercular granulomas are a common manifestation of intraocular tuberculosis. These are said to be hypoxic granulomas with increased expression of vascular endothelial growth factor (VEGF). Management of these granulomas includes a combination of antitubercular therapy (ATT) and oral corticosteroids. We report a case of tubercular granuloma with exudative retinal detachment which was treated with weekly intravitreal anti-VEGF and antibiotic injections along with ATT and corticosteroids. The VEGF levels measured paralleled with the clinical regression of the granuloma. Wolters Kluwer - Medknow 2020-09 2020-08-20 /pmc/articles/PMC7690512/ /pubmed/32823472 http://dx.doi.org/10.4103/ijo.IJO_1261_20 Text en Copyright: © 2020 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Reports
Agarwal, Manisha
Gupta, Chanda
Mohan, K Varsha
Upadhyay, Pramod K
Jha, Vivek
Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma
title Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma
title_full Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma
title_fullStr Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma
title_full_unstemmed Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma
title_short Correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma
title_sort correlation of vascular endothelial growth factor with the clinical regression of tubercular granuloma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690512/
https://www.ncbi.nlm.nih.gov/pubmed/32823472
http://dx.doi.org/10.4103/ijo.IJO_1261_20
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