Tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate

Pediatric intermediate uveitis (IU), usually idiopathic, can also be associated with tuberculosis (TB) and sarcoidosis. A 14-year-old girl was diagnosed with idiopathic IU after ruling out TB and sarcoid. She was treated with oral steroids and methotrexate (MTX) with good inflammation control. One y...

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Autores principales: Nair, Nivedita, Sudharshan, S, Ram Prakash, M, Khetan, Vikas, Rao, Chetan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690549/
https://www.ncbi.nlm.nih.gov/pubmed/32823474
http://dx.doi.org/10.4103/ijo.IJO_362_20
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author Nair, Nivedita
Sudharshan, S
Ram Prakash, M
Khetan, Vikas
Rao, Chetan
author_facet Nair, Nivedita
Sudharshan, S
Ram Prakash, M
Khetan, Vikas
Rao, Chetan
author_sort Nair, Nivedita
collection PubMed
description Pediatric intermediate uveitis (IU), usually idiopathic, can also be associated with tuberculosis (TB) and sarcoidosis. A 14-year-old girl was diagnosed with idiopathic IU after ruling out TB and sarcoid. She was treated with oral steroids and methotrexate (MTX) with good inflammation control. One year later, she presented with subretinal (SR) abscess. Lab tests were still negative but aqueous polymerase chain reaction confirmed TB. With antituberculosis treatment, complete resolution of the lesion was noted. The likelihood of a change in phenotype of ocular TB, from an IU to TB SR abscess or a possible reactivation of latent TB due to MTX are discussed.
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spelling pubmed-76905492020-12-30 Tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate Nair, Nivedita Sudharshan, S Ram Prakash, M Khetan, Vikas Rao, Chetan Indian J Ophthalmol Case Reports Pediatric intermediate uveitis (IU), usually idiopathic, can also be associated with tuberculosis (TB) and sarcoidosis. A 14-year-old girl was diagnosed with idiopathic IU after ruling out TB and sarcoid. She was treated with oral steroids and methotrexate (MTX) with good inflammation control. One year later, she presented with subretinal (SR) abscess. Lab tests were still negative but aqueous polymerase chain reaction confirmed TB. With antituberculosis treatment, complete resolution of the lesion was noted. The likelihood of a change in phenotype of ocular TB, from an IU to TB SR abscess or a possible reactivation of latent TB due to MTX are discussed. Wolters Kluwer - Medknow 2020-09 2020-08-20 /pmc/articles/PMC7690549/ /pubmed/32823474 http://dx.doi.org/10.4103/ijo.IJO_362_20 Text en Copyright: © 2020 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Reports
Nair, Nivedita
Sudharshan, S
Ram Prakash, M
Khetan, Vikas
Rao, Chetan
Tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate
title Tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate
title_full Tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate
title_fullStr Tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate
title_full_unstemmed Tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate
title_short Tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate
title_sort tubercular subretinal abscess in a pediatric intermediate uveitis patient on methotrexate
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690549/
https://www.ncbi.nlm.nih.gov/pubmed/32823474
http://dx.doi.org/10.4103/ijo.IJO_362_20
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