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Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90

Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecules designed to inhibit brain heat shock protein 9...

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Detalles Bibliográficos
Autores principales:	Badolo, Lassina, Thirstrup, Kenneth, Nielsen, Søren Møller, Püschl, Ask, Jensen, Thomas, Watson, Steve, Bundgaard, Christoffer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690585/ https://www.ncbi.nlm.nih.gov/pubmed/33105895 http://dx.doi.org/10.3390/pharmaceutics12111009

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