Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for fam...

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Detalles Bibliográficos
Autores principales: Ceglie, Giulia, Del Baldo, Giada, Agolini, Emanuele, Rinelli, Martina, Cacchione, Antonella, Del Bufalo, Francesca, Vinci, Maria, Carta, Roberto, Boccuto, Luigi, Miele, Evelina, Mastronuzzi, Angela, Locatelli, Franco, Carai, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690624/
https://www.ncbi.nlm.nih.gov/pubmed/33282797
http://dx.doi.org/10.3389/fped.2020.561487
Descripción
Sumario:Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.

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