Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for fam...

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Autores principales: Ceglie, Giulia, Del Baldo, Giada, Agolini, Emanuele, Rinelli, Martina, Cacchione, Antonella, Del Bufalo, Francesca, Vinci, Maria, Carta, Roberto, Boccuto, Luigi, Miele, Evelina, Mastronuzzi, Angela, Locatelli, Franco, Carai, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690624/
https://www.ncbi.nlm.nih.gov/pubmed/33282797
http://dx.doi.org/10.3389/fped.2020.561487
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author Ceglie, Giulia
Del Baldo, Giada
Agolini, Emanuele
Rinelli, Martina
Cacchione, Antonella
Del Bufalo, Francesca
Vinci, Maria
Carta, Roberto
Boccuto, Luigi
Miele, Evelina
Mastronuzzi, Angela
Locatelli, Franco
Carai, Andrea
author_facet Ceglie, Giulia
Del Baldo, Giada
Agolini, Emanuele
Rinelli, Martina
Cacchione, Antonella
Del Bufalo, Francesca
Vinci, Maria
Carta, Roberto
Boccuto, Luigi
Miele, Evelina
Mastronuzzi, Angela
Locatelli, Franco
Carai, Andrea
author_sort Ceglie, Giulia
collection PubMed
description Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.
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spelling pubmed-76906242020-12-04 Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas Ceglie, Giulia Del Baldo, Giada Agolini, Emanuele Rinelli, Martina Cacchione, Antonella Del Bufalo, Francesca Vinci, Maria Carta, Roberto Boccuto, Luigi Miele, Evelina Mastronuzzi, Angela Locatelli, Franco Carai, Andrea Front Pediatr Pediatrics Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling. Frontiers Media S.A. 2020-11-12 /pmc/articles/PMC7690624/ /pubmed/33282797 http://dx.doi.org/10.3389/fped.2020.561487 Text en Copyright © 2020 Ceglie, Del Baldo, Agolini, Rinelli, Cacchione, Del Bufalo, Vinci, Carta, Boccuto, Miele, Mastronuzzi, Locatelli and Carai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Ceglie, Giulia
Del Baldo, Giada
Agolini, Emanuele
Rinelli, Martina
Cacchione, Antonella
Del Bufalo, Francesca
Vinci, Maria
Carta, Roberto
Boccuto, Luigi
Miele, Evelina
Mastronuzzi, Angela
Locatelli, Franco
Carai, Andrea
Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas
title Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas
title_full Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas
title_fullStr Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas
title_full_unstemmed Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas
title_short Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas
title_sort cancer predisposition syndromes associated with pediatric high-grade gliomas
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690624/
https://www.ncbi.nlm.nih.gov/pubmed/33282797
http://dx.doi.org/10.3389/fped.2020.561487
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