Cargando…
Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study
Gold nanoparticles offer the possibility to combine both imaging and therapy of otherwise difficult to treat tumors. To validate and further improve their potential, we describe the use of gold nanostars that were functionalized with a polyethyleneglycol-maleimide coating for in vitro and in vivo ph...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690792/ https://www.ncbi.nlm.nih.gov/pubmed/33114177 http://dx.doi.org/10.3390/nano10112112 |
_version_ | 1783614149011439616 |
---|---|
author | D’Hollander, Antoine Vande Velde, Greetje Jans, Hilde Vanspauwen, Bram Vermeersch, Elien Jose, Jithin Struys, Tom Stakenborg, Tim Lagae, Liesbet Himmelreich, Uwe |
author_facet | D’Hollander, Antoine Vande Velde, Greetje Jans, Hilde Vanspauwen, Bram Vermeersch, Elien Jose, Jithin Struys, Tom Stakenborg, Tim Lagae, Liesbet Himmelreich, Uwe |
author_sort | D’Hollander, Antoine |
collection | PubMed |
description | Gold nanoparticles offer the possibility to combine both imaging and therapy of otherwise difficult to treat tumors. To validate and further improve their potential, we describe the use of gold nanostars that were functionalized with a polyethyleneglycol-maleimide coating for in vitro and in vivo photoacoustic imaging (PAI), computed tomography (CT), as well as photothermal therapy (PTT) of cancer cells and tumor masses, respectively. Nanostar shaped particles show a high absorption coefficient in the near infrared region and have a hydrodynamic size in biological medium around 100 nm, which allows optimal intra-tumoral retention. Using these nanostars for in vitro labeling of tumor cells, high intracellular nanostar concentrations could be achieved, resulting in high PAI and CT contrast and effective PTT. By injecting the nanostars intratumorally, high contrast could be generated in vivo using PAI and CT, which allowed successful multi-modal tumor imaging. PTT was successfully induced, resulting in tumor cell death and subsequent inhibition of tumor growth. Therefore, gold nanostars are versatile theranostic agents for tumor therapy. |
format | Online Article Text |
id | pubmed-7690792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76907922020-11-27 Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study D’Hollander, Antoine Vande Velde, Greetje Jans, Hilde Vanspauwen, Bram Vermeersch, Elien Jose, Jithin Struys, Tom Stakenborg, Tim Lagae, Liesbet Himmelreich, Uwe Nanomaterials (Basel) Article Gold nanoparticles offer the possibility to combine both imaging and therapy of otherwise difficult to treat tumors. To validate and further improve their potential, we describe the use of gold nanostars that were functionalized with a polyethyleneglycol-maleimide coating for in vitro and in vivo photoacoustic imaging (PAI), computed tomography (CT), as well as photothermal therapy (PTT) of cancer cells and tumor masses, respectively. Nanostar shaped particles show a high absorption coefficient in the near infrared region and have a hydrodynamic size in biological medium around 100 nm, which allows optimal intra-tumoral retention. Using these nanostars for in vitro labeling of tumor cells, high intracellular nanostar concentrations could be achieved, resulting in high PAI and CT contrast and effective PTT. By injecting the nanostars intratumorally, high contrast could be generated in vivo using PAI and CT, which allowed successful multi-modal tumor imaging. PTT was successfully induced, resulting in tumor cell death and subsequent inhibition of tumor growth. Therefore, gold nanostars are versatile theranostic agents for tumor therapy. MDPI 2020-10-23 /pmc/articles/PMC7690792/ /pubmed/33114177 http://dx.doi.org/10.3390/nano10112112 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article D’Hollander, Antoine Vande Velde, Greetje Jans, Hilde Vanspauwen, Bram Vermeersch, Elien Jose, Jithin Struys, Tom Stakenborg, Tim Lagae, Liesbet Himmelreich, Uwe Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study |
title | Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study |
title_full | Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study |
title_fullStr | Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study |
title_full_unstemmed | Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study |
title_short | Assessment of the Theranostic Potential of Gold Nanostars—A Multimodal Imaging and Photothermal Treatment Study |
title_sort | assessment of the theranostic potential of gold nanostars—a multimodal imaging and photothermal treatment study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690792/ https://www.ncbi.nlm.nih.gov/pubmed/33114177 http://dx.doi.org/10.3390/nano10112112 |
work_keys_str_mv | AT dhollanderantoine assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT vandeveldegreetje assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT janshilde assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT vanspauwenbram assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT vermeerschelien assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT josejithin assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT struystom assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT stakenborgtim assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT lagaeliesbet assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy AT himmelreichuwe assessmentofthetheranosticpotentialofgoldnanostarsamultimodalimagingandphotothermaltreatmentstudy |