Cargando…

An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling

SIMPLE SUMMARY: Personalized cancer treatments show decreased side-effects and improved treatment success. One aspect of individualized treatment is the timing of medicine intake, which may be optimized based on the biological diurnal rhythm of the patient. The personal biological time can be assess...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hesse, Janina, Malhan, Deeksha, Yalҫin, Müge, Aboumanify, Ouda, Basti, Alireza, Relógio, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690897/ https://www.ncbi.nlm.nih.gov/pubmed/33114254 http://dx.doi.org/10.3390/cancers12113103

Ejemplares similares

A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer
por: Hesse, Janina, et al.
Publicado: (2021)

Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes
por: Malhan, Deeksha, et al.
Publicado: (2022)

Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day
por: Basti, Alireza, et al.
Publicado: (2021)

A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes
por: Yalçin, Müge, et al.
Publicado: (2021)

The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in a Zebrafish Xenograft Colon Cancer Model
por: Basti, Alireza, et al.
Publicado: (2020)

Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells
por: Basti, Alireza, et al.
Publicado: (2022)

An integrative mathematical model for timing treatment toxicity and Zeitgeber impact in colorectal cancer cells
por: Hesse, Janina, et al.
Publicado: (2023)

Circadian Dysregulation of the TGFβ/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells
por: Li, Yin, et al.
Publicado: (2020)

TimeTeller for timing health: The potential of circadian medicine to improve performance, prevent disease and optimize treatment
por: Dose, Benjamin, et al.
Publicado: (2023)

Molecular characterization of the circadian clock in paediatric leukaemia patients: a prospective study protocol
por: Ludwig, Marius, et al.
Publicado: (2023)

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent
por: Malhan, Deeksha, et al.
Publicado: (2023)

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line
por: Genov, Nikolai, et al.
Publicado: (2019)

Circadian regulation in aging: Implications for spaceflight and life on earth
por: Malhan, Deeksha, et al.
Publicado: (2023)

The reciprocal interplay between TNFα and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells
por: Abreu, Mónica, et al.
Publicado: (2018)

Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock
por: Fuhr, Luise, et al.
Publicado: (2022)

Circadian systems biology: When time matters
por: Fuhr, Luise, et al.
Publicado: (2015)

Sex and age-dependent characterization of the circadian clock as a potential biomarker for physical performance: A prospective study protocol
por: Yalçin, Müge, et al.
Publicado: (2023)

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health
por: Yalçin, Müge, et al.
Publicado: (2022)

Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease
por: Yalçin, Müge, et al.
Publicado: (2020)

Differential expression of the circadian clock network correlates with tumour progression in gliomas
por: Petkovic, Marina, et al.
Publicado: (2023)

The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction
por: Mazzoccoli, Gianluigi, et al.
Publicado: (2020)

Temporal Splicing Switches in Elements of the TNF-Pathway Identified by Computational Analysis of Transcriptome Data for Human Cell Lines
por: Genov, Nikolai, et al.
Publicado: (2019)

Time optimal entrainment control for circadian rhythm
por: Julius, A. Agung, et al.
Publicado: (2019)

A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model
por: Schulze, Felix, et al.
Publicado: (2017)

The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia
por: Murgo, Emanuele, et al.
Publicado: (2023)

Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea
por: Gaspar, Laetitia S., et al.
Publicado: (2021)

A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer
por: El-Athman, Rukeia, et al.
Publicado: (2018)

Circadian clocks and memory: time-place learning
por: Mulder, C. K., et al.
Publicado: (2013)

What time is it? Deep learning approaches for circadian rhythms
por: Agostinelli, Forest, et al.
Publicado: (2016)

What time is it? Deep learning approaches for circadian rhythms
por: Agostinelli, Forest, et al.
Publicado: (2016)

Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops
por: Relógio, Angela, et al.
Publicado: (2011)

Mathematics for machine learning
por: Deisenroth, Marc Peter, et al.
Publicado: (2020)

A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events
por: El-Athman, Rukeia, et al.
Publicado: (2019)

Optimal intensive care outcome prediction over time using machine learning
por: Meiring, Christopher, et al.
Publicado: (2018)

Oxytocin in the Circadian Timing of Birth
por: Roizen, Jeffrey, et al.
Publicado: (2007)

Chronotypes and circadian timing in migraine
por: van Oosterhout, WPJ, et al.
Publicado: (2017)

Circadian Metabolomics in Time and Space
por: Dyar, Kenneth A., et al.
Publicado: (2017)

Phosphorylation and Circadian Molecular Timing
por: Brenna, Andrea, et al.
Publicado: (2020)

TimeTrial: An Interactive Application for Optimizing the Design and Analysis of Transcriptomic Time-Series Data in Circadian Biology Research
por: Ness-Cohn, Elan, et al.
Publicado: (2020)

Temperature-induced changes of spike timing precision and network synchronisation
por: Schleimer, Jan-Hendrik, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6gmg0gia620nchiabfi84rpij9