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Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation
In this article, we report a case with pleuroparenchymal fibroelastosis (PPFE) following hematopoietic stem cell transplantation (HSCT) that developed acute respiratory failure with new bilateral ground glass opacity, which could not be explained by either a pulmonary infection, drug toxicity or ext...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691016/ https://www.ncbi.nlm.nih.gov/pubmed/32669500 http://dx.doi.org/10.2169/internalmedicine.4995-20 |
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author | Murakami, Yasushi Sakamoto, Koji Okumura, Yuki Suzuki, Atsushi Mii, Shinji Sato, Mitsuo Yokoi, Toyoharu Hashimoto, Naozumi Hasegawa, Yoshinori |
author_facet | Murakami, Yasushi Sakamoto, Koji Okumura, Yuki Suzuki, Atsushi Mii, Shinji Sato, Mitsuo Yokoi, Toyoharu Hashimoto, Naozumi Hasegawa, Yoshinori |
author_sort | Murakami, Yasushi |
collection | PubMed |
description | In this article, we report a case with pleuroparenchymal fibroelastosis (PPFE) following hematopoietic stem cell transplantation (HSCT) that developed acute respiratory failure with new bilateral ground glass opacity, which could not be explained by either a pulmonary infection, drug toxicity or extraparenchymal causes. Although combination therapy with multiple immunosuppressants was transiently effective, the patient died from a recurrent exacerbation. Autopsied lungs demonstrated diffuse alveolar damage superimposed on PPFE. There was no evidence of any coexisting interstitial pneumonia with the usual interstitial pneumonia (UIP) pattern. Our case suggests that acute exacerbation can occur in patients with post-HSCT PPFE, even when a coexisting UIP pattern is absent. |
format | Online Article Text |
id | pubmed-7691016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-76910162020-12-03 Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation Murakami, Yasushi Sakamoto, Koji Okumura, Yuki Suzuki, Atsushi Mii, Shinji Sato, Mitsuo Yokoi, Toyoharu Hashimoto, Naozumi Hasegawa, Yoshinori Intern Med Case Report In this article, we report a case with pleuroparenchymal fibroelastosis (PPFE) following hematopoietic stem cell transplantation (HSCT) that developed acute respiratory failure with new bilateral ground glass opacity, which could not be explained by either a pulmonary infection, drug toxicity or extraparenchymal causes. Although combination therapy with multiple immunosuppressants was transiently effective, the patient died from a recurrent exacerbation. Autopsied lungs demonstrated diffuse alveolar damage superimposed on PPFE. There was no evidence of any coexisting interstitial pneumonia with the usual interstitial pneumonia (UIP) pattern. Our case suggests that acute exacerbation can occur in patients with post-HSCT PPFE, even when a coexisting UIP pattern is absent. The Japanese Society of Internal Medicine 2020-07-14 2020-11-01 /pmc/articles/PMC7691016/ /pubmed/32669500 http://dx.doi.org/10.2169/internalmedicine.4995-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Murakami, Yasushi Sakamoto, Koji Okumura, Yuki Suzuki, Atsushi Mii, Shinji Sato, Mitsuo Yokoi, Toyoharu Hashimoto, Naozumi Hasegawa, Yoshinori Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation |
title | Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation |
title_full | Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation |
title_fullStr | Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation |
title_full_unstemmed | Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation |
title_short | Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation |
title_sort | acute exacerbation of pleuroparenchymal fibroelastosis secondary to allogenic hematopoietic stem cell transplantation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691016/ https://www.ncbi.nlm.nih.gov/pubmed/32669500 http://dx.doi.org/10.2169/internalmedicine.4995-20 |
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