Acute Interstitial Nephritis and Acute Tubular Injury Due to a Transdermal Loxoprofen Patch

A transdermal patch formulation of a non-steroidal anti-inflammatory drug (NSAID) used by a 44-year-old man resulted in acute interstitial nephritis and acute tubular injury. This patient also had a history of mild kidney dysfunction and osteoporosis. The NSAID patch had been prescribed after a traf...

Descripción completa

Detalles Bibliográficos
Autores principales: Shinzato, Takahiro, Ohara, Ken, Kaminaga, Hiroaki, Sugase, Taro, Masuda, Takahiro, Nagata, Daisuke, Saki, Katano, Kinoshita, Yoshitaka, Kubo, Taro, Shimizu, Toshihiro, Nanmoku, Koji, Yagisawa, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691042/
https://www.ncbi.nlm.nih.gov/pubmed/33132307
http://dx.doi.org/10.2169/internalmedicine.4945-20
Descripción
Sumario:A transdermal patch formulation of a non-steroidal anti-inflammatory drug (NSAID) used by a 44-year-old man resulted in acute interstitial nephritis and acute tubular injury. This patient also had a history of mild kidney dysfunction and osteoporosis. The NSAID patch had been prescribed after a traffic accident. He was also receiving a vitamin D analog and taking over-the-counter calcium supplements. Two months later, renal dysfunction and hypercalcemia were discovered. A renal biopsy showed acute interstitial nephritis and acute tubular injury. Once these agents were withdrawn, the renal function recovered. This is the first reported occurrence of biopsy-proven acute interstitial nephritis attributable to NSAID patch usage.

Ejemplares similares