Cargando…

Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions

The issues of pyrethroid resistance and outdoor malaria parasite transmission have prompted the WHO to call for the development and adoption of viable alternative vector control methods. Larval source management is one of the core malaria vector interventions recommended by the Ministry of Health in...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Guofa, Lo, Eugenia, Githeko, Andrew K., Afrane, Yaw A., Yan, Guiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691065/
https://www.ncbi.nlm.nih.gov/pubmed/33243294
http://dx.doi.org/10.1186/s40249-020-00767-3
_version_ 1783614209241645056
author Zhou, Guofa
Lo, Eugenia
Githeko, Andrew K.
Afrane, Yaw A.
Yan, Guiyun
author_facet Zhou, Guofa
Lo, Eugenia
Githeko, Andrew K.
Afrane, Yaw A.
Yan, Guiyun
author_sort Zhou, Guofa
collection PubMed
description The issues of pyrethroid resistance and outdoor malaria parasite transmission have prompted the WHO to call for the development and adoption of viable alternative vector control methods. Larval source management is one of the core malaria vector interventions recommended by the Ministry of Health in many African countries, but it is rarely implemented due to concerns on its cost-effectiveness. New long-lasting microbial larvicide can be a promising cost-effective supplement to current vector control and elimination methods because microbial larvicide uses killing mechanisms different from pyrethroids and other chemical insecticides. It has been shown to be effective in reducing the overall vector abundance and thus both indoor and outdoor transmission. In our opinion, the long-lasting formulation can potentially reduce the cost of larvicide field application, and should be evaluated for its cost-effectiveness, resistance development, and impact on non-target organisms when integrating with other malaria vector control measures. In this opinion, we highlight that long-lasting microbial larvicide can be a potential cost-effective product that complements current front-line long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) programs for malaria control and elimination. Microbial larviciding targets immature mosquitoes, reduces both indoor and outdoor transmission and is not affected by vector resistance to synthetic insecticides. This control method is a shift from the conventional LLINs and IRS programs that mainly target indoor-biting and resting adult mosquitoes.
format Online
Article
Text
id pubmed-7691065
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-76910652020-11-30 Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions Zhou, Guofa Lo, Eugenia Githeko, Andrew K. Afrane, Yaw A. Yan, Guiyun Infect Dis Poverty Opinion The issues of pyrethroid resistance and outdoor malaria parasite transmission have prompted the WHO to call for the development and adoption of viable alternative vector control methods. Larval source management is one of the core malaria vector interventions recommended by the Ministry of Health in many African countries, but it is rarely implemented due to concerns on its cost-effectiveness. New long-lasting microbial larvicide can be a promising cost-effective supplement to current vector control and elimination methods because microbial larvicide uses killing mechanisms different from pyrethroids and other chemical insecticides. It has been shown to be effective in reducing the overall vector abundance and thus both indoor and outdoor transmission. In our opinion, the long-lasting formulation can potentially reduce the cost of larvicide field application, and should be evaluated for its cost-effectiveness, resistance development, and impact on non-target organisms when integrating with other malaria vector control measures. In this opinion, we highlight that long-lasting microbial larvicide can be a potential cost-effective product that complements current front-line long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) programs for malaria control and elimination. Microbial larviciding targets immature mosquitoes, reduces both indoor and outdoor transmission and is not affected by vector resistance to synthetic insecticides. This control method is a shift from the conventional LLINs and IRS programs that mainly target indoor-biting and resting adult mosquitoes. BioMed Central 2020-11-26 /pmc/articles/PMC7691065/ /pubmed/33243294 http://dx.doi.org/10.1186/s40249-020-00767-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Opinion
Zhou, Guofa
Lo, Eugenia
Githeko, Andrew K.
Afrane, Yaw A.
Yan, Guiyun
Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions
title Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions
title_full Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions
title_fullStr Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions
title_full_unstemmed Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions
title_short Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions
title_sort long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691065/
https://www.ncbi.nlm.nih.gov/pubmed/33243294
http://dx.doi.org/10.1186/s40249-020-00767-3
work_keys_str_mv AT zhouguofa longlastingmicrobiallarvicidesforcontrollinginsecticideresistantandoutdoortransmittingvectorsacosteffectivesupplementformalariainterventions
AT loeugenia longlastingmicrobiallarvicidesforcontrollinginsecticideresistantandoutdoortransmittingvectorsacosteffectivesupplementformalariainterventions
AT githekoandrewk longlastingmicrobiallarvicidesforcontrollinginsecticideresistantandoutdoortransmittingvectorsacosteffectivesupplementformalariainterventions
AT afraneyawa longlastingmicrobiallarvicidesforcontrollinginsecticideresistantandoutdoortransmittingvectorsacosteffectivesupplementformalariainterventions
AT yanguiyun longlastingmicrobiallarvicidesforcontrollinginsecticideresistantandoutdoortransmittingvectorsacosteffectivesupplementformalariainterventions