Nucleic Acid-Based Technologies Targeting Coronaviruses

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics, and therapeutics. Nucleic acid (NA)-based t...

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Detalles Bibliográficos
Autores principales: Le, Thi Khanh, Paris, Clément, Khan, Khadija Shahed, Robson, Fran, Ng, Wai-Lung, Rocchi, Palma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691141/
https://www.ncbi.nlm.nih.gov/pubmed/33309323
http://dx.doi.org/10.1016/j.tibs.2020.11.010
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author Le, Thi Khanh
Paris, Clément
Khan, Khadija Shahed
Robson, Fran
Ng, Wai-Lung
Rocchi, Palma
author_facet Le, Thi Khanh
Paris, Clément
Khan, Khadija Shahed
Robson, Fran
Ng, Wai-Lung
Rocchi, Palma
author_sort Le, Thi Khanh
collection PubMed
description The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics, and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-CoV NA-based technologies, including antisense oligonucleotides (ASOs), siRNAs, RNA-targeting clustered regularly interspaced short palindromic repeats-CRISPR-associated protein (CRISPR-Cas), and mRNA vaccines, and discuss improved delivery methods and combination therapies with other antiviral drugs.
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spelling pubmed-76911412020-11-27 Nucleic Acid-Based Technologies Targeting Coronaviruses Le, Thi Khanh Paris, Clément Khan, Khadija Shahed Robson, Fran Ng, Wai-Lung Rocchi, Palma Trends Biochem Sci Review The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics, and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-CoV NA-based technologies, including antisense oligonucleotides (ASOs), siRNAs, RNA-targeting clustered regularly interspaced short palindromic repeats-CRISPR-associated protein (CRISPR-Cas), and mRNA vaccines, and discuss improved delivery methods and combination therapies with other antiviral drugs. Elsevier Ltd. 2021-05 2020-11-27 /pmc/articles/PMC7691141/ /pubmed/33309323 http://dx.doi.org/10.1016/j.tibs.2020.11.010 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Le, Thi Khanh
Paris, Clément
Khan, Khadija Shahed
Robson, Fran
Ng, Wai-Lung
Rocchi, Palma
Nucleic Acid-Based Technologies Targeting Coronaviruses
title Nucleic Acid-Based Technologies Targeting Coronaviruses
title_full Nucleic Acid-Based Technologies Targeting Coronaviruses
title_fullStr Nucleic Acid-Based Technologies Targeting Coronaviruses
title_full_unstemmed Nucleic Acid-Based Technologies Targeting Coronaviruses
title_short Nucleic Acid-Based Technologies Targeting Coronaviruses
title_sort nucleic acid-based technologies targeting coronaviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691141/
https://www.ncbi.nlm.nih.gov/pubmed/33309323
http://dx.doi.org/10.1016/j.tibs.2020.11.010
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