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Overview of Plasma and Platelet Transfusions in Critically Ill Children

Critically ill children are a unique population who frequently receive plasma and platelet transfusions for both active bleeding and mitigation of bleeding risk. While these products are frequently administered, transfusion indications in this population remain unclear, and practice varies across in...

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Autores principales: Kahn, Stacie, Chegondi, Madhuradhar, Nellis, Marianne E., Karam, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691248/
https://www.ncbi.nlm.nih.gov/pubmed/33282804
http://dx.doi.org/10.3389/fped.2020.601659
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author Kahn, Stacie
Chegondi, Madhuradhar
Nellis, Marianne E.
Karam, Oliver
author_facet Kahn, Stacie
Chegondi, Madhuradhar
Nellis, Marianne E.
Karam, Oliver
author_sort Kahn, Stacie
collection PubMed
description Critically ill children are a unique population who frequently receive plasma and platelet transfusions for both active bleeding and mitigation of bleeding risk. While these products are frequently administered, transfusion indications in this population remain unclear, and practice varies across institutions and providers. In this manuscript, we will outline the current evidence regarding plasma and platelet transfusions for hemostasis in the pediatric intensive care setting. For both products, we will describe the product composition, epidemiology, and product indications and discuss the potential risks and benefits involved with the transfusion. We will also discuss knowledge gaps and future areas of research.
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spelling pubmed-76912482020-12-04 Overview of Plasma and Platelet Transfusions in Critically Ill Children Kahn, Stacie Chegondi, Madhuradhar Nellis, Marianne E. Karam, Oliver Front Pediatr Pediatrics Critically ill children are a unique population who frequently receive plasma and platelet transfusions for both active bleeding and mitigation of bleeding risk. While these products are frequently administered, transfusion indications in this population remain unclear, and practice varies across institutions and providers. In this manuscript, we will outline the current evidence regarding plasma and platelet transfusions for hemostasis in the pediatric intensive care setting. For both products, we will describe the product composition, epidemiology, and product indications and discuss the potential risks and benefits involved with the transfusion. We will also discuss knowledge gaps and future areas of research. Frontiers Media S.A. 2020-11-13 /pmc/articles/PMC7691248/ /pubmed/33282804 http://dx.doi.org/10.3389/fped.2020.601659 Text en Copyright © 2020 Kahn, Chegondi, Nellis and Karam. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Kahn, Stacie
Chegondi, Madhuradhar
Nellis, Marianne E.
Karam, Oliver
Overview of Plasma and Platelet Transfusions in Critically Ill Children
title Overview of Plasma and Platelet Transfusions in Critically Ill Children
title_full Overview of Plasma and Platelet Transfusions in Critically Ill Children
title_fullStr Overview of Plasma and Platelet Transfusions in Critically Ill Children
title_full_unstemmed Overview of Plasma and Platelet Transfusions in Critically Ill Children
title_short Overview of Plasma and Platelet Transfusions in Critically Ill Children
title_sort overview of plasma and platelet transfusions in critically ill children
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691248/
https://www.ncbi.nlm.nih.gov/pubmed/33282804
http://dx.doi.org/10.3389/fped.2020.601659
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