Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges

Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and includes micro-RNA (miRNA) deregulation. The understanding of the role of miRNAs in PAH is expanding quickly, and it is increasi...

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Autores principales: Santos-Ferreira, Cátia A., Abreu, Mónica T., Marques, Carla I., Gonçalves, Lino M., Baptista, Rui, Girão, Henrique M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
State-of-the-Art Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691282/
https://www.ncbi.nlm.nih.gov/pubmed/33294743
http://dx.doi.org/10.1016/j.jacbts.2020.07.008
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author Santos-Ferreira, Cátia A.
Abreu, Mónica T.
Marques, Carla I.
Gonçalves, Lino M.
Baptista, Rui
Girão, Henrique M.
author_facet Santos-Ferreira, Cátia A.
Abreu, Mónica T.
Marques, Carla I.
Gonçalves, Lino M.
Baptista, Rui
Girão, Henrique M.
author_sort Santos-Ferreira, Cátia A.
collection PubMed
description Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and includes micro-RNA (miRNA) deregulation. The understanding of the role of miRNAs in PAH is expanding quickly, and it is increasingly difficult to identify which miRNAs have the highest translational potential. This review summarizes the current knowledge of miRNA expression in PAH, discusses the challenges in miRNA analysis and interpretation, and highlights 4 promising miRNAs in this field (miR-29, miR-124, miR-140, and miR-204).
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spelling pubmed-76912822020-12-07 Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges Santos-Ferreira, Cátia A. Abreu, Mónica T. Marques, Carla I. Gonçalves, Lino M. Baptista, Rui Girão, Henrique M. JACC Basic Transl Sci State-of-the-Art Review Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and includes micro-RNA (miRNA) deregulation. The understanding of the role of miRNAs in PAH is expanding quickly, and it is increasingly difficult to identify which miRNAs have the highest translational potential. This review summarizes the current knowledge of miRNA expression in PAH, discusses the challenges in miRNA analysis and interpretation, and highlights 4 promising miRNAs in this field (miR-29, miR-124, miR-140, and miR-204). Elsevier 2020-11-23 /pmc/articles/PMC7691282/ /pubmed/33294743 http://dx.doi.org/10.1016/j.jacbts.2020.07.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle State-of-the-Art Review
Santos-Ferreira, Cátia A.
Abreu, Mónica T.
Marques, Carla I.
Gonçalves, Lino M.
Baptista, Rui
Girão, Henrique M.
Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges
title Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges
title_full Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges
title_fullStr Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges
title_full_unstemmed Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges
title_short Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges
title_sort micro-rna analysis in pulmonary arterial hypertension: current knowledge and challenges
topic State-of-the-Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691282/
https://www.ncbi.nlm.nih.gov/pubmed/33294743
http://dx.doi.org/10.1016/j.jacbts.2020.07.008
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