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β-Arrestin–Biased AT(1) Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate

The treatment of pediatric heart failure is a long-standing unmet medical need. Angiotensin II supports mammalian perinatal circulation by activating cardiac L-type Ca(2+) channels through angiotensin type 1 receptor (AT(1)R) and β-arrestin. TRV027, a β-arrestin–biased AT(1)R agonist, that has been...

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Detalles Bibliográficos
Autores principales:	Kashihara, Toshihide, Kawagishi, Hiroyuki, Nakada, Tsutomu, Numaga-Tomita, Takuro, Kadota, Shin, Wolf, Elena E., Du, Cheng-Kun, Shiba, Yuji, Morimoto, Sachio, Yamada, Mitsuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Preclinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691286/ https://www.ncbi.nlm.nih.gov/pubmed/33294739 http://dx.doi.org/10.1016/j.jacbts.2020.08.011

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