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Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking

The hyperpolarization-activated cation current I(f) is a key determinant for cardiac pacemaker activity. It is conducted by subunits of the hyperpolarization-activated cyclic nucleotide–gated (HCN) channel family, of which HCN4 is predominant in mammalian heart. Both loss-of-function and gain-of-fun...

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Detalles Bibliográficos
Autores principales:	Erlenhardt, Nadine, Kletke, Olaf, Wohlfarth, Franziska, Komadowski, Marlene A., Clasen, Lukas, Makimoto, Hisaki, Rinné, Susanne, Kelm, Malte, Jungen, Christiane, Decher, Niels, Meyer, Christian, Klöcker, Nikolaj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691308/ https://www.ncbi.nlm.nih.gov/pubmed/33095298 http://dx.doi.org/10.1007/s00424-020-02481-3

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