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Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice

The incidence of non-alcoholic fatty liver disease (NAFLD) is rising annually, and emerging evidence suggests that the gut bacteria plays a causal role in NAFLD. Naringin, a natural flavanone enriched in citrus fruits, is reported to reduce hepatic lipid accumulation, but to date, no investigations...

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Autores principales: Mu, Hongna, Zhou, Qi, Yang, Ruiyue, Zeng, Jie, Li, Xianghui, Zhang, Ranran, Tang, Weiqing, Li, Hongxia, Wang, Siming, Shen, Tao, Huang, Xiuqing, Dou, Lin, Dong, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691324/
https://www.ncbi.nlm.nih.gov/pubmed/33281780
http://dx.doi.org/10.3389/fmicb.2020.585066
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author Mu, Hongna
Zhou, Qi
Yang, Ruiyue
Zeng, Jie
Li, Xianghui
Zhang, Ranran
Tang, Weiqing
Li, Hongxia
Wang, Siming
Shen, Tao
Huang, Xiuqing
Dou, Lin
Dong, Jun
author_facet Mu, Hongna
Zhou, Qi
Yang, Ruiyue
Zeng, Jie
Li, Xianghui
Zhang, Ranran
Tang, Weiqing
Li, Hongxia
Wang, Siming
Shen, Tao
Huang, Xiuqing
Dou, Lin
Dong, Jun
author_sort Mu, Hongna
collection PubMed
description The incidence of non-alcoholic fatty liver disease (NAFLD) is rising annually, and emerging evidence suggests that the gut bacteria plays a causal role in NAFLD. Naringin, a natural flavanone enriched in citrus fruits, is reported to reduce hepatic lipid accumulation, but to date, no investigations have examined whether the benefits of naringin are associated with the gut bacteria. Thus, we investigated whether the antilipidemic effects of naringin are related to modulating the gut bacteria and metabolic functions. In this study, C57BL/6J mice were fed a high-fat diet (HFD) for 8 weeks, then fed an HFD with or without naringin administration for another 8 weeks. Naringin intervention reduced the body weight gain, liver lipid accumulation, and lipogenesis and attenuated plasma biochemical parameters in HFD-fed mice. Gut bacteria analysis showed that naringin altered the community compositional structure of the gut bacteria characterized by increased benefits and fewer harmful bacteria. Additionally, Spearman’s correlation analysis showed that at the genus level, Allobaculum, Alloprevotella, Butyricicoccus, Lachnospiraceae_NK4A136_group, Parasutterella and uncultured_bacterium_f_Muribaculaceae were negatively correlated and Campylobacter, Coriobacteriaceae_UCG-002, Faecalibaculum and Fusobacterium were positively correlated with serum lipid levels. These results strongly suggest that naringin may be used as a potential agent to prevent gut dysbiosis and alleviate NAFLD.
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spelling pubmed-76913242020-12-04 Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice Mu, Hongna Zhou, Qi Yang, Ruiyue Zeng, Jie Li, Xianghui Zhang, Ranran Tang, Weiqing Li, Hongxia Wang, Siming Shen, Tao Huang, Xiuqing Dou, Lin Dong, Jun Front Microbiol Microbiology The incidence of non-alcoholic fatty liver disease (NAFLD) is rising annually, and emerging evidence suggests that the gut bacteria plays a causal role in NAFLD. Naringin, a natural flavanone enriched in citrus fruits, is reported to reduce hepatic lipid accumulation, but to date, no investigations have examined whether the benefits of naringin are associated with the gut bacteria. Thus, we investigated whether the antilipidemic effects of naringin are related to modulating the gut bacteria and metabolic functions. In this study, C57BL/6J mice were fed a high-fat diet (HFD) for 8 weeks, then fed an HFD with or without naringin administration for another 8 weeks. Naringin intervention reduced the body weight gain, liver lipid accumulation, and lipogenesis and attenuated plasma biochemical parameters in HFD-fed mice. Gut bacteria analysis showed that naringin altered the community compositional structure of the gut bacteria characterized by increased benefits and fewer harmful bacteria. Additionally, Spearman’s correlation analysis showed that at the genus level, Allobaculum, Alloprevotella, Butyricicoccus, Lachnospiraceae_NK4A136_group, Parasutterella and uncultured_bacterium_f_Muribaculaceae were negatively correlated and Campylobacter, Coriobacteriaceae_UCG-002, Faecalibaculum and Fusobacterium were positively correlated with serum lipid levels. These results strongly suggest that naringin may be used as a potential agent to prevent gut dysbiosis and alleviate NAFLD. Frontiers Media S.A. 2020-11-13 /pmc/articles/PMC7691324/ /pubmed/33281780 http://dx.doi.org/10.3389/fmicb.2020.585066 Text en Copyright © 2020 Mu, Zhou, Yang, Zeng, Li, Zhang, Tang, Li, Wang, Shen, Huang, Dou and Dong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Mu, Hongna
Zhou, Qi
Yang, Ruiyue
Zeng, Jie
Li, Xianghui
Zhang, Ranran
Tang, Weiqing
Li, Hongxia
Wang, Siming
Shen, Tao
Huang, Xiuqing
Dou, Lin
Dong, Jun
Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice
title Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice
title_full Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice
title_fullStr Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice
title_full_unstemmed Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice
title_short Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice
title_sort naringin attenuates high fat diet induced non-alcoholic fatty liver disease and gut bacterial dysbiosis in mice
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691324/
https://www.ncbi.nlm.nih.gov/pubmed/33281780
http://dx.doi.org/10.3389/fmicb.2020.585066
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