Cargando…
Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice
The incidence of non-alcoholic fatty liver disease (NAFLD) is rising annually, and emerging evidence suggests that the gut bacteria plays a causal role in NAFLD. Naringin, a natural flavanone enriched in citrus fruits, is reported to reduce hepatic lipid accumulation, but to date, no investigations...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691324/ https://www.ncbi.nlm.nih.gov/pubmed/33281780 http://dx.doi.org/10.3389/fmicb.2020.585066 |
_version_ | 1783614264612749312 |
---|---|
author | Mu, Hongna Zhou, Qi Yang, Ruiyue Zeng, Jie Li, Xianghui Zhang, Ranran Tang, Weiqing Li, Hongxia Wang, Siming Shen, Tao Huang, Xiuqing Dou, Lin Dong, Jun |
author_facet | Mu, Hongna Zhou, Qi Yang, Ruiyue Zeng, Jie Li, Xianghui Zhang, Ranran Tang, Weiqing Li, Hongxia Wang, Siming Shen, Tao Huang, Xiuqing Dou, Lin Dong, Jun |
author_sort | Mu, Hongna |
collection | PubMed |
description | The incidence of non-alcoholic fatty liver disease (NAFLD) is rising annually, and emerging evidence suggests that the gut bacteria plays a causal role in NAFLD. Naringin, a natural flavanone enriched in citrus fruits, is reported to reduce hepatic lipid accumulation, but to date, no investigations have examined whether the benefits of naringin are associated with the gut bacteria. Thus, we investigated whether the antilipidemic effects of naringin are related to modulating the gut bacteria and metabolic functions. In this study, C57BL/6J mice were fed a high-fat diet (HFD) for 8 weeks, then fed an HFD with or without naringin administration for another 8 weeks. Naringin intervention reduced the body weight gain, liver lipid accumulation, and lipogenesis and attenuated plasma biochemical parameters in HFD-fed mice. Gut bacteria analysis showed that naringin altered the community compositional structure of the gut bacteria characterized by increased benefits and fewer harmful bacteria. Additionally, Spearman’s correlation analysis showed that at the genus level, Allobaculum, Alloprevotella, Butyricicoccus, Lachnospiraceae_NK4A136_group, Parasutterella and uncultured_bacterium_f_Muribaculaceae were negatively correlated and Campylobacter, Coriobacteriaceae_UCG-002, Faecalibaculum and Fusobacterium were positively correlated with serum lipid levels. These results strongly suggest that naringin may be used as a potential agent to prevent gut dysbiosis and alleviate NAFLD. |
format | Online Article Text |
id | pubmed-7691324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76913242020-12-04 Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice Mu, Hongna Zhou, Qi Yang, Ruiyue Zeng, Jie Li, Xianghui Zhang, Ranran Tang, Weiqing Li, Hongxia Wang, Siming Shen, Tao Huang, Xiuqing Dou, Lin Dong, Jun Front Microbiol Microbiology The incidence of non-alcoholic fatty liver disease (NAFLD) is rising annually, and emerging evidence suggests that the gut bacteria plays a causal role in NAFLD. Naringin, a natural flavanone enriched in citrus fruits, is reported to reduce hepatic lipid accumulation, but to date, no investigations have examined whether the benefits of naringin are associated with the gut bacteria. Thus, we investigated whether the antilipidemic effects of naringin are related to modulating the gut bacteria and metabolic functions. In this study, C57BL/6J mice were fed a high-fat diet (HFD) for 8 weeks, then fed an HFD with or without naringin administration for another 8 weeks. Naringin intervention reduced the body weight gain, liver lipid accumulation, and lipogenesis and attenuated plasma biochemical parameters in HFD-fed mice. Gut bacteria analysis showed that naringin altered the community compositional structure of the gut bacteria characterized by increased benefits and fewer harmful bacteria. Additionally, Spearman’s correlation analysis showed that at the genus level, Allobaculum, Alloprevotella, Butyricicoccus, Lachnospiraceae_NK4A136_group, Parasutterella and uncultured_bacterium_f_Muribaculaceae were negatively correlated and Campylobacter, Coriobacteriaceae_UCG-002, Faecalibaculum and Fusobacterium were positively correlated with serum lipid levels. These results strongly suggest that naringin may be used as a potential agent to prevent gut dysbiosis and alleviate NAFLD. Frontiers Media S.A. 2020-11-13 /pmc/articles/PMC7691324/ /pubmed/33281780 http://dx.doi.org/10.3389/fmicb.2020.585066 Text en Copyright © 2020 Mu, Zhou, Yang, Zeng, Li, Zhang, Tang, Li, Wang, Shen, Huang, Dou and Dong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Mu, Hongna Zhou, Qi Yang, Ruiyue Zeng, Jie Li, Xianghui Zhang, Ranran Tang, Weiqing Li, Hongxia Wang, Siming Shen, Tao Huang, Xiuqing Dou, Lin Dong, Jun Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice |
title | Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice |
title_full | Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice |
title_fullStr | Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice |
title_full_unstemmed | Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice |
title_short | Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice |
title_sort | naringin attenuates high fat diet induced non-alcoholic fatty liver disease and gut bacterial dysbiosis in mice |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691324/ https://www.ncbi.nlm.nih.gov/pubmed/33281780 http://dx.doi.org/10.3389/fmicb.2020.585066 |
work_keys_str_mv | AT muhongna naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT zhouqi naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT yangruiyue naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT zengjie naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT lixianghui naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT zhangranran naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT tangweiqing naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT lihongxia naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT wangsiming naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT shentao naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT huangxiuqing naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT doulin naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice AT dongjun naringinattenuateshighfatdietinducednonalcoholicfattyliverdiseaseandgutbacterialdysbiosisinmice |