Deep eutectic solvents for solid pesticide dosage forms

Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containi...

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Autores principales: Phillips, Justin, Focke, Walter W., du Toit, Elizabeth L., Wesley-Smith, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691325/
https://www.ncbi.nlm.nih.gov/pubmed/33244109
http://dx.doi.org/10.1038/s41598-020-77559-0
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author Phillips, Justin
Focke, Walter W.
du Toit, Elizabeth L.
Wesley-Smith, James
author_facet Phillips, Justin
Focke, Walter W.
du Toit, Elizabeth L.
Wesley-Smith, James
author_sort Phillips, Justin
collection PubMed
description Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.
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spelling pubmed-76913252020-11-27 Deep eutectic solvents for solid pesticide dosage forms Phillips, Justin Focke, Walter W. du Toit, Elizabeth L. Wesley-Smith, James Sci Rep Article Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix. Nature Publishing Group UK 2020-11-26 /pmc/articles/PMC7691325/ /pubmed/33244109 http://dx.doi.org/10.1038/s41598-020-77559-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Phillips, Justin
Focke, Walter W.
du Toit, Elizabeth L.
Wesley-Smith, James
Deep eutectic solvents for solid pesticide dosage forms
title Deep eutectic solvents for solid pesticide dosage forms
title_full Deep eutectic solvents for solid pesticide dosage forms
title_fullStr Deep eutectic solvents for solid pesticide dosage forms
title_full_unstemmed Deep eutectic solvents for solid pesticide dosage forms
title_short Deep eutectic solvents for solid pesticide dosage forms
title_sort deep eutectic solvents for solid pesticide dosage forms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691325/
https://www.ncbi.nlm.nih.gov/pubmed/33244109
http://dx.doi.org/10.1038/s41598-020-77559-0
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