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Excavating the functionally crucial active-site residues of the DXS protein of Bacillus subtilis by exploring its closest homologues

BACKGROUND: To achieve a high yield of terpenoid-based therapeutics, 1-deoxy-d-xylulose-5-phosphate (DXP) pathway has been significantly exploited for the production of downstream enzymes. The DXP synthase (DXS) enzyme, the initiator of this pathway, is pivotal for the convergence of carbon flux, an...

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Detalles Bibliográficos
Autores principales: Runthala, Ashish, Sai, Tavakala Harsha, Kamjula, Vandana, Phulara, Suresh C., Rajput, Vikrant Singh, Sangapillai, Karthikeyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691408/
https://www.ncbi.nlm.nih.gov/pubmed/33242110
http://dx.doi.org/10.1186/s43141-020-00087-x