Comparisons of Four Protein-Binding Models Characterizing the Pharmacokinetics of Unbound Phenytoin in Adult Patients Using Non-Linear Mixed-Effects Modeling

BACKGROUND AND OBJECTIVE: Phenytoin is extensively protein bound with a narrow therapeutic range. The unbound phenytoin is pharmacologically active, but total concentrations are routinely measured in clinical practice. The relationship between free and total phenytoin has been described by various b...

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Detalles Bibliográficos
Autores principales: Jun, Heajin, Rong, Yan, Yih, Catharina, Ho, Jordan, Cheng, Wendy, Kiang, Tony K. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691416/
https://www.ncbi.nlm.nih.gov/pubmed/33026608
http://dx.doi.org/10.1007/s40268-020-00323-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691416/
https://www.ncbi.nlm.nih.gov/pubmed/33026608
http://dx.doi.org/10.1007/s40268-020-00323-2

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