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Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism. We analyze 2,114 post-mortem brain transcriptomes and identify genes in the alternative bile acid synthesis pathway to be expressed...
Autores principales: | Baloni, Priyanka, Funk, Cory C., Yan, Jingwen, Yurkovich, James T., Kueider-Paisley, Alexandra, Nho, Kwangsik, Heinken, Almut, Jia, Wei, Mahmoudiandehkordi, Siamak, Louie, Gregory, Saykin, Andrew J., Arnold, Matthias, Kastenmüller, Gabi, Griffiths, William J., Thiele, Ines, Kaddurah-Daouk, Rima, Price, Nathan D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691449/ https://www.ncbi.nlm.nih.gov/pubmed/33294859 http://dx.doi.org/10.1016/j.xcrm.2020.100138 |
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