Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances

Chemokine-like factor (CKLF)–like MARVEL transmembrane domain-containing family (CMTMs) is a new gene family, consisting of CKLF and CMTM1 to CMTM8, which plays an important role in hematopoiesis system, autoimmune diseases, male reproduction etc. Abnormal expression of CMTMs is also associated with...

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Autores principales: Li, Mengxia, Luo, Fangzhou, Tian, Xinyao, Yin, Shengyong, Zhou, Lin, Zheng, Shusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691587/
https://www.ncbi.nlm.nih.gov/pubmed/33282744
http://dx.doi.org/10.3389/fonc.2020.595973
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author Li, Mengxia
Luo, Fangzhou
Tian, Xinyao
Yin, Shengyong
Zhou, Lin
Zheng, Shusen
author_facet Li, Mengxia
Luo, Fangzhou
Tian, Xinyao
Yin, Shengyong
Zhou, Lin
Zheng, Shusen
author_sort Li, Mengxia
collection PubMed
description Chemokine-like factor (CKLF)–like MARVEL transmembrane domain-containing family (CMTMs) is a new gene family, consisting of CKLF and CMTM1 to CMTM8, which plays an important role in hematopoiesis system, autoimmune diseases, male reproduction etc. Abnormal expression of CMTMs is also associated with tumor genesis, development and metastasis. In this review, we briefly describe the characteristics of CMTM family, outline its functions in multiple kinds of carcinomas, and summarize the latest research on their roles in hepatocellular carcinoma which are mainly related to the expression, prognostic effect, potential functions, and mechanism of action. The CMTM family is expected to provide new ideas and targets for HCC diagnosis and treatment.
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spelling pubmed-76915872020-12-04 Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances Li, Mengxia Luo, Fangzhou Tian, Xinyao Yin, Shengyong Zhou, Lin Zheng, Shusen Front Oncol Oncology Chemokine-like factor (CKLF)–like MARVEL transmembrane domain-containing family (CMTMs) is a new gene family, consisting of CKLF and CMTM1 to CMTM8, which plays an important role in hematopoiesis system, autoimmune diseases, male reproduction etc. Abnormal expression of CMTMs is also associated with tumor genesis, development and metastasis. In this review, we briefly describe the characteristics of CMTM family, outline its functions in multiple kinds of carcinomas, and summarize the latest research on their roles in hepatocellular carcinoma which are mainly related to the expression, prognostic effect, potential functions, and mechanism of action. The CMTM family is expected to provide new ideas and targets for HCC diagnosis and treatment. Frontiers Media S.A. 2020-11-13 /pmc/articles/PMC7691587/ /pubmed/33282744 http://dx.doi.org/10.3389/fonc.2020.595973 Text en Copyright © 2020 Li, Luo, Tian, Yin, Zhou and Zheng http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Mengxia
Luo, Fangzhou
Tian, Xinyao
Yin, Shengyong
Zhou, Lin
Zheng, Shusen
Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances
title Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances
title_full Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances
title_fullStr Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances
title_full_unstemmed Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances
title_short Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances
title_sort chemokine-like factor-like marvel transmembrane domain-containing family in hepatocellular carcinoma: latest advances
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691587/
https://www.ncbi.nlm.nih.gov/pubmed/33282744
http://dx.doi.org/10.3389/fonc.2020.595973
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