Cargando…

Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer

BACKGROUND & OBJECTIVE: Nowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors. This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Borhan, Armin, Nozarian, Zohreh, Abdollahi, Alireza, Shahsiah, Reza, Mohammadpour, Hadiseh, Borhan, Arash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691711/
https://www.ncbi.nlm.nih.gov/pubmed/33391377
http://dx.doi.org/10.30699/ijp.2020.121532.2322
_version_ 1783614352053501952
author Borhan, Armin
Nozarian, Zohreh
Abdollahi, Alireza
Shahsiah, Reza
Mohammadpour, Hadiseh
Borhan, Arash
author_facet Borhan, Armin
Nozarian, Zohreh
Abdollahi, Alireza
Shahsiah, Reza
Mohammadpour, Hadiseh
Borhan, Arash
author_sort Borhan, Armin
collection PubMed
description BACKGROUND & OBJECTIVE: Nowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors. This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with breast cancer. METHODS: The included population consisted of 40 confirmed cases of female breast cancer (including 20 patients with breast cancer along with axillary lymph node metastasis and 20 patients without axillary lymph node metastasis). Expression of Villin and Gelsolin genes was evaluated using Real-time PCR and pre-designed primers. RESULTS: The mean expression level of Villin in groups with and without axillary lymph node metastasis was 3.33±1.35 and 0.87±0.88, respectively (P<0.001). The mean Gelsolin expression levels in both groups (with and without axillary lymph node metastasis) were 4.13±2.40 and 1.00±0.35, respectively (P<0.001). The significant relationships were independent of individuals’ age. CONCLUSION: Patients with axillary lymph node metastasis may express significant higher level of Villin and Gelsolin genes.
format Online
Article
Text
id pubmed-7691711
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Iranian Society of Pathology
record_format MEDLINE/PubMed
spelling pubmed-76917112021-01-01 Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer Borhan, Armin Nozarian, Zohreh Abdollahi, Alireza Shahsiah, Reza Mohammadpour, Hadiseh Borhan, Arash Iran J Pathol Original Article BACKGROUND & OBJECTIVE: Nowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors. This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with breast cancer. METHODS: The included population consisted of 40 confirmed cases of female breast cancer (including 20 patients with breast cancer along with axillary lymph node metastasis and 20 patients without axillary lymph node metastasis). Expression of Villin and Gelsolin genes was evaluated using Real-time PCR and pre-designed primers. RESULTS: The mean expression level of Villin in groups with and without axillary lymph node metastasis was 3.33±1.35 and 0.87±0.88, respectively (P<0.001). The mean Gelsolin expression levels in both groups (with and without axillary lymph node metastasis) were 4.13±2.40 and 1.00±0.35, respectively (P<0.001). The significant relationships were independent of individuals’ age. CONCLUSION: Patients with axillary lymph node metastasis may express significant higher level of Villin and Gelsolin genes. Iranian Society of Pathology 2021 2020-10-10 /pmc/articles/PMC7691711/ /pubmed/33391377 http://dx.doi.org/10.30699/ijp.2020.121532.2322 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Borhan, Armin
Nozarian, Zohreh
Abdollahi, Alireza
Shahsiah, Reza
Mohammadpour, Hadiseh
Borhan, Arash
Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer
title Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer
title_full Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer
title_fullStr Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer
title_full_unstemmed Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer
title_short Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer
title_sort evaluation of the relationship between expression of villin and gelsolin genes and axillary lymph node metastasis in patients with breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691711/
https://www.ncbi.nlm.nih.gov/pubmed/33391377
http://dx.doi.org/10.30699/ijp.2020.121532.2322
work_keys_str_mv AT borhanarmin evaluationoftherelationshipbetweenexpressionofvillinandgelsolingenesandaxillarylymphnodemetastasisinpatientswithbreastcancer
AT nozarianzohreh evaluationoftherelationshipbetweenexpressionofvillinandgelsolingenesandaxillarylymphnodemetastasisinpatientswithbreastcancer
AT abdollahialireza evaluationoftherelationshipbetweenexpressionofvillinandgelsolingenesandaxillarylymphnodemetastasisinpatientswithbreastcancer
AT shahsiahreza evaluationoftherelationshipbetweenexpressionofvillinandgelsolingenesandaxillarylymphnodemetastasisinpatientswithbreastcancer
AT mohammadpourhadiseh evaluationoftherelationshipbetweenexpressionofvillinandgelsolingenesandaxillarylymphnodemetastasisinpatientswithbreastcancer
AT borhanarash evaluationoftherelationshipbetweenexpressionofvillinandgelsolingenesandaxillarylymphnodemetastasisinpatientswithbreastcancer