Cargando…

Retinal Spheroids and Axon Pathology Identified in Amyotrophic Lateral Sclerosis

PURPOSE: To determine whether patients with amyotrophic lateral sclerosis (ALS) show retinal axon pathology. METHODS: Postmortem eyes from 10 patients with ALS were sectioned and compared with 10 age-matched controls. Retinal sections were evaluated with periodic acid Schiff and phosphorylated (P-NF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharma, Kieran, Amin Mohammed Amin, Maryam, Gupta, Neeru, Zinman, Lorne, Zhou, Xun, Irving, Hyacinth, Yücel, Yeni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Anatomy and Pathology/Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691787/ https://www.ncbi.nlm.nih.gov/pubmed/33226405 http://dx.doi.org/10.1167/iovs.61.13.30

Ejemplares similares

Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm
por: Conceição, Raquel, et al.
Publicado: (2019)

Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis
por: Kawamoto, Yuko, et al.
Publicado: (2022)

Primary Cilia in Amacrine Cells in Retinal Development
por: Ning, Ke, et al.
Publicado: (2021)

Ambient Light Regulates Retinal Dopamine Signaling and Myopia Susceptibility
por: Landis, Erica G., et al.
Publicado: (2021)

Molecular, Cellular, and Functional Heterogeneity of Retinal and Choroidal Endothelial Cells
por: Kim, Soo Jin, et al.
Publicado: (2023)

Retinal OFF-Pathway Overstimulation Leads to Greater Accommodation-Induced Choroidal Thinning
por: Hoseini-Yazdi, Hosein, et al.
Publicado: (2021)

Oral Selumetinib Does Not Negatively Impact Photoreceptor Survival in Murine Experimental Retinal Detachment
por: Cebulla, Colleen M., et al.
Publicado: (2019)

Pattern Recognition Analysis of Age-Related Retinal Ganglion Cell Signatures in the Human Eye
por: Yoshioka, Nayuta, et al.
Publicado: (2017)

Temporal Relationship Between Visual Field, Retinal and Microvascular Pathology Following (125)I-Plaque Brachytherapy for Uveal Melanoma
por: Tamplin, Michelle R., et al.
Publicado: (2021)

Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model
por: Kaczmarek, Jessica V., et al.
Publicado: (2021)

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)
por: Yunusova, Yana, et al.
Publicado: (2011)

Morphological analyses of the retinal photoreceptor cells in the nocturnally adapted owl monkeys
por: KUNIYOSHI, Nobue, et al.
Publicado: (2018)

Smog Sign: Hazy Diffusion-weighted Imaging Restriction in Dense Axonal Tracts in the Pons on Hyperacute MRI with Remarkable Clinical Improvement After Intra-arterial Thrombectomy
por: Ikram, Asad, et al.
Publicado: (2019)

Adjuvant Chemotherapy Improves Survival for Children With Massive Choroidal Invasion of Retinoblastoma
por: Feng, Zhao Xun, et al.
Publicado: (2023)

Dysregulated axonal RNA translation in amyotrophic lateral sclerosis
por: Yasuda, Kyota, et al.
Publicado: (2016)

A Thick Anastomotic Vein Between Cephalic and Lateral Radial Veins: Clinical Significance of an Unusual Variation
por: Adanır, Saliha Seda, et al.
Publicado: (2021)

Prevalence, Laterality, and Classification of Ossified Petroclival Ligaments: An Anatomical and Histological Study With Application to Skull Base Surgery
por: Ekanem, Uduak-Obong I, et al.
Publicado: (2023)

Neuropathologic description of CHCHD10 mutated amyotrophic lateral sclerosis
por: Keith, Julia L., et al.
Publicado: (2020)

Retinal nerve fiber layer in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
por: Wong, Bryan M., et al.
Publicado: (2022)

Rate of speech decline in individuals with amyotrophic lateral sclerosis
por: Eshghi, Marziye, et al.
Publicado: (2022)

Subtle retinal pathology in amyotrophic lateral sclerosis
por: Ringelstein, Marius, et al.
Publicado: (2014)

Cerebral atrophy in amyotrophic lateral sclerosis parallels the pathological distribution of TDP43
por: Dadar, Mahsa, et al.
Publicado: (2020)

A novel photoacoustic-fluorescent contrast agent for quantitative imaging of lymphatic drainage
por: Cardinell, Kirsten, et al.
Publicado: (2021)

Breached Barriers: A Scoping Review of Blood-Central Nervous System Barrier Pathology in Amyotrophic Lateral Sclerosis
por: Mirian, Ario, et al.
Publicado: (2022)

Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis
por: Yunusova, Yana, et al.
Publicado: (2019)

Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway
por: Lesnick, Timothy G., et al.
Publicado: (2008)

Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis
por: Iwai, Yuta, et al.
Publicado: (2016)

Plasma taurine is an axonal excitability-translatable biomarker for amyotrophic lateral sclerosis
por: Nakazato, Tomoko, et al.
Publicado: (2022)

Retinal Damage in Amyotrophic Lateral Sclerosis: Underlying Mechanisms
por: Soldatov, Vladislav O, et al.
Publicado: (2021)

Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems
por: Rong, Panying, et al.
Publicado: (2016)

Nonhuman Primate Ocular Biometry
por: Augusteyn, Robert C., et al.
Publicado: (2016)

Growth and Metastasis of Intraocular Tumors in Aged Mice
por: Han, Zhiqiang, et al.
Publicado: (2016)

Expression Profiling of Ascorbic Acid–Related Transporters in Human and Mouse Eyes
por: Ma, Nan, et al.
Publicado: (2016)

The Effects of the Relative Strength of Simultaneous Competing Defocus Signals on Emmetropization in Infant Rhesus Monkeys
por: Arumugam, Baskar, et al.
Publicado: (2016)

Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia
por: Harper, Angelica R., et al.
Publicado: (2016)

Development of Experimental Myopia in Chicks in a Natural Environment
por: Stone, Richard A., et al.
Publicado: (2016)

The Targetable Epigenetic Tumor Protein EZH2 is Enriched in Intraocular Medulloepithelioma
por: Avedschmidt, Sarah E., et al.
Publicado: (2016)

Genome-Wide Scleral Micro- and Messenger-RNA Regulation During Myopia Development in the Mouse
por: Metlapally, Ravikanth, et al.
Publicado: (2016)

ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells
por: Kaochar, Salma, et al.
Publicado: (2018)

Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma
por: Daniels, Anthony B., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ec8q2fvnov8cbt36ebtoduio2v