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Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease
BACKGROUND: Evidence suggests that glucocorticoids are important in the treatment of sudden hearing loss (SHL) and Meniere’s disease (MD). However, different glucocorticoid administration methods may have a significant impact on treatment outcomes. OBJECTIVE: This study aimed to investigate effects...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese PLA General Hospital
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691840/ https://www.ncbi.nlm.nih.gov/pubmed/33293916 http://dx.doi.org/10.1016/j.joto.2020.08.003 |
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author | Chen, Dan Li, Zhipeng Zhou, Qilin Chen, Yubin Yang, Luoying Tan, Jingqian Zeng, Xiangli Li, Peng |
author_facet | Chen, Dan Li, Zhipeng Zhou, Qilin Chen, Yubin Yang, Luoying Tan, Jingqian Zeng, Xiangli Li, Peng |
author_sort | Chen, Dan |
collection | PubMed |
description | BACKGROUND: Evidence suggests that glucocorticoids are important in the treatment of sudden hearing loss (SHL) and Meniere’s disease (MD). However, different glucocorticoid administration methods may have a significant impact on treatment outcomes. OBJECTIVE: This study aimed to investigate effects of different glucocorticoid administration methods on sudden hearing loss and Meniere’s disease. METHODS: In this study, glucocorticoids were administered orally in 18 patients, by retroauricular injection in 15 patients and by intratympanic injection in 15 patients. White blood cell (WBC) count, serum K(+), fasting plasma glucose (FPG), body temperature, heart rate and blood pressure were used to evaluate effects of glucocorticoids on patients with hearing loss. Visual analog scale (VAS) of pain and sleep disorders were also surveyed, and pure tone audiometry (PTA) results were compared among groups to evaluate efficacy of different glucocorticoids administration methods. RESULT: WBC count, heart rate and blood pressure were higher in patients taking oral glucocorticoids, while body temperature, serum K(+) and FPG levels did not change in all three groups. However, patients who received intratympanic injection of glucocorticoids experienced more pain, while those taking oral glucocorticoids reported more sleep impairment. Treatment efficacy on hearing loss was not significantly different among the three groups. CONCLUSION: These findings suggest that systemic glucocorticoid administration can result in greater whole body responses than local administration, but with similar hearing treatment efficacy. |
format | Online Article Text |
id | pubmed-7691840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Chinese PLA General Hospital |
record_format | MEDLINE/PubMed |
spelling | pubmed-76918402020-12-07 Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease Chen, Dan Li, Zhipeng Zhou, Qilin Chen, Yubin Yang, Luoying Tan, Jingqian Zeng, Xiangli Li, Peng J Otol Research Article BACKGROUND: Evidence suggests that glucocorticoids are important in the treatment of sudden hearing loss (SHL) and Meniere’s disease (MD). However, different glucocorticoid administration methods may have a significant impact on treatment outcomes. OBJECTIVE: This study aimed to investigate effects of different glucocorticoid administration methods on sudden hearing loss and Meniere’s disease. METHODS: In this study, glucocorticoids were administered orally in 18 patients, by retroauricular injection in 15 patients and by intratympanic injection in 15 patients. White blood cell (WBC) count, serum K(+), fasting plasma glucose (FPG), body temperature, heart rate and blood pressure were used to evaluate effects of glucocorticoids on patients with hearing loss. Visual analog scale (VAS) of pain and sleep disorders were also surveyed, and pure tone audiometry (PTA) results were compared among groups to evaluate efficacy of different glucocorticoids administration methods. RESULT: WBC count, heart rate and blood pressure were higher in patients taking oral glucocorticoids, while body temperature, serum K(+) and FPG levels did not change in all three groups. However, patients who received intratympanic injection of glucocorticoids experienced more pain, while those taking oral glucocorticoids reported more sleep impairment. Treatment efficacy on hearing loss was not significantly different among the three groups. CONCLUSION: These findings suggest that systemic glucocorticoid administration can result in greater whole body responses than local administration, but with similar hearing treatment efficacy. Chinese PLA General Hospital 2020-12 2020-08-22 /pmc/articles/PMC7691840/ /pubmed/33293916 http://dx.doi.org/10.1016/j.joto.2020.08.003 Text en © 2020 PLA General Hospital Department of Otolaryngology Head and Neck Surgery. Production and hosting by Elsevier (Singapore) Pte Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Chen, Dan Li, Zhipeng Zhou, Qilin Chen, Yubin Yang, Luoying Tan, Jingqian Zeng, Xiangli Li, Peng Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease |
title | Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease |
title_full | Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease |
title_fullStr | Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease |
title_full_unstemmed | Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease |
title_short | Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease |
title_sort | impacts of different methylprednisolone administration routes in patients with sudden hearing loss or meniere’s disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691840/ https://www.ncbi.nlm.nih.gov/pubmed/33293916 http://dx.doi.org/10.1016/j.joto.2020.08.003 |
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