The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review

Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance. Finding new treatment directions and targets for cancer prognosis and reducing mortality has become a top priority. OCT4...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Han, Zhenzhen, Zhu, Yanbo, Chen, Jingcheng, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691851/
https://www.ncbi.nlm.nih.gov/pubmed/32840233
http://dx.doi.org/10.15283/ijsc20097
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author Zhang, Qi
Han, Zhenzhen
Zhu, Yanbo
Chen, Jingcheng
Li, Wei
author_facet Zhang, Qi
Han, Zhenzhen
Zhu, Yanbo
Chen, Jingcheng
Li, Wei
author_sort Zhang, Qi
collection PubMed
description Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance. Finding new treatment directions and targets for cancer prognosis and reducing mortality has become a top priority. OCT4, as a transcription factor, participates in maintaining the stem characteristics of CSCs, but the mechanism of OCT4 is often overlooked. In this review, we try to illustrate the mechanism by which OCT4 plays a role in CSCs from the perspective of genetic modification of OCT4, non-coding RNA, complexes and signaling pathways associated with OCT4. Our ultimate goal is to provide new targets for cancer treatment to prolong the survival of cancer patients.
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spelling pubmed-76918512020-12-07 The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review Zhang, Qi Han, Zhenzhen Zhu, Yanbo Chen, Jingcheng Li, Wei Int J Stem Cells Review Article Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance. Finding new treatment directions and targets for cancer prognosis and reducing mortality has become a top priority. OCT4, as a transcription factor, participates in maintaining the stem characteristics of CSCs, but the mechanism of OCT4 is often overlooked. In this review, we try to illustrate the mechanism by which OCT4 plays a role in CSCs from the perspective of genetic modification of OCT4, non-coding RNA, complexes and signaling pathways associated with OCT4. Our ultimate goal is to provide new targets for cancer treatment to prolong the survival of cancer patients. Korean Society for Stem Cell Research 2020-08-31 /pmc/articles/PMC7691851/ /pubmed/32840233 http://dx.doi.org/10.15283/ijsc20097 Text en Copyright © 2020 by the Korean Society for Stem Cell Research This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Qi
Han, Zhenzhen
Zhu, Yanbo
Chen, Jingcheng
Li, Wei
The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review
title The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review
title_full The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review
title_fullStr The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review
title_full_unstemmed The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review
title_short The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review
title_sort role and specific mechanism of oct4 in cancer stem cells: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691851/
https://www.ncbi.nlm.nih.gov/pubmed/32840233
http://dx.doi.org/10.15283/ijsc20097
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