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Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations
Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was condu...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691911/ https://www.ncbi.nlm.nih.gov/pubmed/33282162 http://dx.doi.org/10.1177/2036361320973526 |
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author | Mezi, Silvia Pomati, Giulia Botticelli, Andrea De Felice, Francesca Musio, Daniela della Monaca, Marco Amirhassankhani, Sasan Vullo, Francesco Cerbelli, Bruna Carletti, Raffaella Di Gioia, Cira Catalano, Carlo Valentini, Valentino Tombolini, Vincenzo Della Rocca, Carlo Marchetti, Paolo |
author_facet | Mezi, Silvia Pomati, Giulia Botticelli, Andrea De Felice, Francesca Musio, Daniela della Monaca, Marco Amirhassankhani, Sasan Vullo, Francesco Cerbelli, Bruna Carletti, Raffaella Di Gioia, Cira Catalano, Carlo Valentini, Valentino Tombolini, Vincenzo Della Rocca, Carlo Marchetti, Paolo |
author_sort | Mezi, Silvia |
collection | PubMed |
description | Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was conducted, along with analysis of the association between treatment, clinical/pathological characteristics, and outcomes. Most patients (8) were staged IVa, with the majority of them (10) having G3 fast growing cancer. Local and systemic recurrence were reported in only three out of nine parotid cases (0 out of 2 submandibular SCGs). In two out of eight patients local relapse occurred after integrated treatment, while recurrence occurred in two out of three patients undergoing exclusive surgery. Five patients eventually died. Treatment of resectable disease must be aggressive and multimodal, with achievement of loco-regional control in order to reduce rate of recurrence and improve outcomes. Metastatic disease would require a therapeutic strategy tailored to the molecular profile in order to improve the currently disappointing results. |
format | Online Article Text |
id | pubmed-7691911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-76919112020-12-04 Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations Mezi, Silvia Pomati, Giulia Botticelli, Andrea De Felice, Francesca Musio, Daniela della Monaca, Marco Amirhassankhani, Sasan Vullo, Francesco Cerbelli, Bruna Carletti, Raffaella Di Gioia, Cira Catalano, Carlo Valentini, Valentino Tombolini, Vincenzo Della Rocca, Carlo Marchetti, Paolo Rare Tumors Original Research Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was conducted, along with analysis of the association between treatment, clinical/pathological characteristics, and outcomes. Most patients (8) were staged IVa, with the majority of them (10) having G3 fast growing cancer. Local and systemic recurrence were reported in only three out of nine parotid cases (0 out of 2 submandibular SCGs). In two out of eight patients local relapse occurred after integrated treatment, while recurrence occurred in two out of three patients undergoing exclusive surgery. Five patients eventually died. Treatment of resectable disease must be aggressive and multimodal, with achievement of loco-regional control in order to reduce rate of recurrence and improve outcomes. Metastatic disease would require a therapeutic strategy tailored to the molecular profile in order to improve the currently disappointing results. SAGE Publications 2020-11-24 /pmc/articles/PMC7691911/ /pubmed/33282162 http://dx.doi.org/10.1177/2036361320973526 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Mezi, Silvia Pomati, Giulia Botticelli, Andrea De Felice, Francesca Musio, Daniela della Monaca, Marco Amirhassankhani, Sasan Vullo, Francesco Cerbelli, Bruna Carletti, Raffaella Di Gioia, Cira Catalano, Carlo Valentini, Valentino Tombolini, Vincenzo Della Rocca, Carlo Marchetti, Paolo Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations |
title | Primary squamous cell carcinoma of major salivary gland: “Sapienza
Head and Neck Unit” clinical recommendations |
title_full | Primary squamous cell carcinoma of major salivary gland: “Sapienza
Head and Neck Unit” clinical recommendations |
title_fullStr | Primary squamous cell carcinoma of major salivary gland: “Sapienza
Head and Neck Unit” clinical recommendations |
title_full_unstemmed | Primary squamous cell carcinoma of major salivary gland: “Sapienza
Head and Neck Unit” clinical recommendations |
title_short | Primary squamous cell carcinoma of major salivary gland: “Sapienza
Head and Neck Unit” clinical recommendations |
title_sort | primary squamous cell carcinoma of major salivary gland: “sapienza
head and neck unit” clinical recommendations |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691911/ https://www.ncbi.nlm.nih.gov/pubmed/33282162 http://dx.doi.org/10.1177/2036361320973526 |
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