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Amiloride: A review

Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics...

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Detalles Bibliográficos
Autores principales: Sun, Qianhui, Sever, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691917/
https://www.ncbi.nlm.nih.gov/pubmed/33234024
http://dx.doi.org/10.1177/1470320320975893
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author Sun, Qianhui
Sever, Peter
author_facet Sun, Qianhui
Sever, Peter
author_sort Sun, Qianhui
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description Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics for hypertension, congestive heart failure and hepatic cirrhosis with ascites. Historical studies on its use in hypertension were poorly controlled and there is insufficient data on dose-response. It is clearly highly effective in combination with thiazide diuretics where it counteracts the adverse metabolic effects of the thiazides and its use in the Medical Research Council Trial of Older Hypertensive Patients, demonstrated convincing outcome benefits on stroke and coronary events. Recently it has been shown to be as effective as spironolactone in resistant hypertension but there is a real need to establish its potential role in the much larger number of patients with mild to moderate hypertension in whom there is a paucity of information with amiloride particularly across an extended dose range.
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spelling pubmed-76919172020-12-04 Amiloride: A review Sun, Qianhui Sever, Peter J Renin Angiotensin Aldosterone Syst Original Article Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics for hypertension, congestive heart failure and hepatic cirrhosis with ascites. Historical studies on its use in hypertension were poorly controlled and there is insufficient data on dose-response. It is clearly highly effective in combination with thiazide diuretics where it counteracts the adverse metabolic effects of the thiazides and its use in the Medical Research Council Trial of Older Hypertensive Patients, demonstrated convincing outcome benefits on stroke and coronary events. Recently it has been shown to be as effective as spironolactone in resistant hypertension but there is a real need to establish its potential role in the much larger number of patients with mild to moderate hypertension in whom there is a paucity of information with amiloride particularly across an extended dose range. SAGE Publications 2020-11-24 /pmc/articles/PMC7691917/ /pubmed/33234024 http://dx.doi.org/10.1177/1470320320975893 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Sun, Qianhui
Sever, Peter
Amiloride: A review
title Amiloride: A review
title_full Amiloride: A review
title_fullStr Amiloride: A review
title_full_unstemmed Amiloride: A review
title_short Amiloride: A review
title_sort amiloride: a review
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691917/
https://www.ncbi.nlm.nih.gov/pubmed/33234024
http://dx.doi.org/10.1177/1470320320975893
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