Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma

Adverse thromboembolic events following administration of the anti-fibrinolytic agent tranexamic acid (TA), used to prevent/treat excessive blood loss, are rare. We present the clinical course of two young patients (22 and 56 months) receiving busulfan/melphalan (Bu/Mel) high-dose chemotherapy with...

Descripción completa

Detalles Bibliográficos
Autores principales: Zirngibl, Felix, Flemmig, Carina, Lang, Peter, Künkele, Annette, Eggert, Angelika, Schulte, Johannes H., Deubzer, Hedwig E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692027/
https://www.ncbi.nlm.nih.gov/pubmed/33126407
http://dx.doi.org/10.3390/children7110198
_version_ 1783614415541633024
author Zirngibl, Felix
Flemmig, Carina
Lang, Peter
Künkele, Annette
Eggert, Angelika
Schulte, Johannes H.
Deubzer, Hedwig E.
author_facet Zirngibl, Felix
Flemmig, Carina
Lang, Peter
Künkele, Annette
Eggert, Angelika
Schulte, Johannes H.
Deubzer, Hedwig E.
author_sort Zirngibl, Felix
collection PubMed
description Adverse thromboembolic events following administration of the anti-fibrinolytic agent tranexamic acid (TA), used to prevent/treat excessive blood loss, are rare. We present the clinical course of two young patients (22 and 56 months) receiving busulfan/melphalan (Bu/Mel) high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HSCT) to treat high-risk neuroblastoma, who developed hepatic sinusoidal obstruction syndrome (SOS) within 48 h after systemic TA treatment for a hemodynamically relevant hemorrhage. Defibrotide treatment resolved hepatic SOS, but the short time between TA administration and SOS onset suggests a causal association.
format Online
Article
Text
id pubmed-7692027
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76920272020-11-28 Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma Zirngibl, Felix Flemmig, Carina Lang, Peter Künkele, Annette Eggert, Angelika Schulte, Johannes H. Deubzer, Hedwig E. Children (Basel) Case Report Adverse thromboembolic events following administration of the anti-fibrinolytic agent tranexamic acid (TA), used to prevent/treat excessive blood loss, are rare. We present the clinical course of two young patients (22 and 56 months) receiving busulfan/melphalan (Bu/Mel) high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HSCT) to treat high-risk neuroblastoma, who developed hepatic sinusoidal obstruction syndrome (SOS) within 48 h after systemic TA treatment for a hemodynamically relevant hemorrhage. Defibrotide treatment resolved hepatic SOS, but the short time between TA administration and SOS onset suggests a causal association. MDPI 2020-10-28 /pmc/articles/PMC7692027/ /pubmed/33126407 http://dx.doi.org/10.3390/children7110198 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Zirngibl, Felix
Flemmig, Carina
Lang, Peter
Künkele, Annette
Eggert, Angelika
Schulte, Johannes H.
Deubzer, Hedwig E.
Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma
title Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma
title_full Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma
title_fullStr Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma
title_full_unstemmed Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma
title_short Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma
title_sort sinusoidal obstruction syndrome following myeloablative therapy and tranexamic acid treatment for hemorrhage in two patients with neuroblastoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692027/
https://www.ncbi.nlm.nih.gov/pubmed/33126407
http://dx.doi.org/10.3390/children7110198
work_keys_str_mv AT zirngiblfelix sinusoidalobstructionsyndromefollowingmyeloablativetherapyandtranexamicacidtreatmentforhemorrhageintwopatientswithneuroblastoma
AT flemmigcarina sinusoidalobstructionsyndromefollowingmyeloablativetherapyandtranexamicacidtreatmentforhemorrhageintwopatientswithneuroblastoma
AT langpeter sinusoidalobstructionsyndromefollowingmyeloablativetherapyandtranexamicacidtreatmentforhemorrhageintwopatientswithneuroblastoma
AT kunkeleannette sinusoidalobstructionsyndromefollowingmyeloablativetherapyandtranexamicacidtreatmentforhemorrhageintwopatientswithneuroblastoma
AT eggertangelika sinusoidalobstructionsyndromefollowingmyeloablativetherapyandtranexamicacidtreatmentforhemorrhageintwopatientswithneuroblastoma
AT schultejohannesh sinusoidalobstructionsyndromefollowingmyeloablativetherapyandtranexamicacidtreatmentforhemorrhageintwopatientswithneuroblastoma
AT deubzerhedwige sinusoidalobstructionsyndromefollowingmyeloablativetherapyandtranexamicacidtreatmentforhemorrhageintwopatientswithneuroblastoma

Ejemplares similares