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DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy
Due to its immunomodulatory effects and the limitation in the radiological damage progression, disease-modifying antirheumatic drugs (DMARDs) work as first-line rheumatoid arthritis (RA) treatment. In recent years, numerous research projects have suggested that the metabolism of DMARDs could have a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692063/ https://www.ncbi.nlm.nih.gov/pubmed/33114390 http://dx.doi.org/10.3390/biom10111479 |
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author | Zaragoza-García, Oscar Castro-Alarcón, Natividad Pérez-Rubio, Gloria Guzmán-Guzmán, Iris Paola |
author_facet | Zaragoza-García, Oscar Castro-Alarcón, Natividad Pérez-Rubio, Gloria Guzmán-Guzmán, Iris Paola |
author_sort | Zaragoza-García, Oscar |
collection | PubMed |
description | Due to its immunomodulatory effects and the limitation in the radiological damage progression, disease-modifying antirheumatic drugs (DMARDs) work as first-line rheumatoid arthritis (RA) treatment. In recent years, numerous research projects have suggested that the metabolism of DMARDs could have a role in gut dysbiosis, which indicates that the microbiota variability could modify the employment of direct and indirect mechanisms in the response to treatment. The main objective of this review was to understand the gut microbiota bacterial variability in patients with RA, pre and post-treatment with DMARDs, and to identify the possible mechanisms through which microbiota can regulate the response to pharmacological therapy. |
format | Online Article Text |
id | pubmed-7692063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76920632020-11-28 DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy Zaragoza-García, Oscar Castro-Alarcón, Natividad Pérez-Rubio, Gloria Guzmán-Guzmán, Iris Paola Biomolecules Review Due to its immunomodulatory effects and the limitation in the radiological damage progression, disease-modifying antirheumatic drugs (DMARDs) work as first-line rheumatoid arthritis (RA) treatment. In recent years, numerous research projects have suggested that the metabolism of DMARDs could have a role in gut dysbiosis, which indicates that the microbiota variability could modify the employment of direct and indirect mechanisms in the response to treatment. The main objective of this review was to understand the gut microbiota bacterial variability in patients with RA, pre and post-treatment with DMARDs, and to identify the possible mechanisms through which microbiota can regulate the response to pharmacological therapy. MDPI 2020-10-24 /pmc/articles/PMC7692063/ /pubmed/33114390 http://dx.doi.org/10.3390/biom10111479 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zaragoza-García, Oscar Castro-Alarcón, Natividad Pérez-Rubio, Gloria Guzmán-Guzmán, Iris Paola DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy |
title | DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy |
title_full | DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy |
title_fullStr | DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy |
title_full_unstemmed | DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy |
title_short | DMARDs–Gut Microbiota Feedback: Implications in the Response to Therapy |
title_sort | dmards–gut microbiota feedback: implications in the response to therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692063/ https://www.ncbi.nlm.nih.gov/pubmed/33114390 http://dx.doi.org/10.3390/biom10111479 |
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