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A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan

Tick-borne encephalitis (TBE) is a zoonotic disease that usually presents as a moderate febrile illness followed by severe encephalitis, and various neurological symptoms are observed depending on the distinct central nervous system (CNS) regions affected by the TBE virus (TBEV) infection. In Japan,...

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Autores principales: Yoshii, Kentaro, Takahashi-Iwata, Ikuko, Shirai, Shinichi, Kobayashi, Shintaro, Yabe, Ichiro, Sasaki, Hidenao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692117/
https://www.ncbi.nlm.nih.gov/pubmed/33126600
http://dx.doi.org/10.3390/microorganisms8111672
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author Yoshii, Kentaro
Takahashi-Iwata, Ikuko
Shirai, Shinichi
Kobayashi, Shintaro
Yabe, Ichiro
Sasaki, Hidenao
author_facet Yoshii, Kentaro
Takahashi-Iwata, Ikuko
Shirai, Shinichi
Kobayashi, Shintaro
Yabe, Ichiro
Sasaki, Hidenao
author_sort Yoshii, Kentaro
collection PubMed
description Tick-borne encephalitis (TBE) is a zoonotic disease that usually presents as a moderate febrile illness followed by severe encephalitis, and various neurological symptoms are observed depending on the distinct central nervous system (CNS) regions affected by the TBE virus (TBEV) infection. In Japan, TBE incidence is increasing and TBEV distributions are reported in wide areas, specifically in Hokkaido. However, an extensive epidemiological survey regarding TBEV has not been conducted yet. In this study, we conducted a retrospective study of the prevalence of antibodies against TBEV in patients with neurological disorders and healthy populations in a TBEV-endemic area in Hokkaido. Among 2000 patients, three patients with inflammatory diseases in the CNS had TBEV-specific IgM antibodies and neutralizing antibodies. The other four patients diagnosed clinically with other neurological diseases were positive for TBEV-specific IgG and neutralizing antibodies, indicating previous TBEV infection. In a total of 246 healthy residents in a TBEV-endemic region, one resident had TBEV-specific antibodies. These results demonstrated undiagnosed TBEV infections in Japan. Further surveys are required to reveal the actual epidemiological risk of TBE and to consider preventive measures, such as a vaccine program, for the control of TBE in Japan.
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spelling pubmed-76921172020-11-28 A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan Yoshii, Kentaro Takahashi-Iwata, Ikuko Shirai, Shinichi Kobayashi, Shintaro Yabe, Ichiro Sasaki, Hidenao Microorganisms Article Tick-borne encephalitis (TBE) is a zoonotic disease that usually presents as a moderate febrile illness followed by severe encephalitis, and various neurological symptoms are observed depending on the distinct central nervous system (CNS) regions affected by the TBE virus (TBEV) infection. In Japan, TBE incidence is increasing and TBEV distributions are reported in wide areas, specifically in Hokkaido. However, an extensive epidemiological survey regarding TBEV has not been conducted yet. In this study, we conducted a retrospective study of the prevalence of antibodies against TBEV in patients with neurological disorders and healthy populations in a TBEV-endemic area in Hokkaido. Among 2000 patients, three patients with inflammatory diseases in the CNS had TBEV-specific IgM antibodies and neutralizing antibodies. The other four patients diagnosed clinically with other neurological diseases were positive for TBEV-specific IgG and neutralizing antibodies, indicating previous TBEV infection. In a total of 246 healthy residents in a TBEV-endemic region, one resident had TBEV-specific antibodies. These results demonstrated undiagnosed TBEV infections in Japan. Further surveys are required to reveal the actual epidemiological risk of TBE and to consider preventive measures, such as a vaccine program, for the control of TBE in Japan. MDPI 2020-10-28 /pmc/articles/PMC7692117/ /pubmed/33126600 http://dx.doi.org/10.3390/microorganisms8111672 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoshii, Kentaro
Takahashi-Iwata, Ikuko
Shirai, Shinichi
Kobayashi, Shintaro
Yabe, Ichiro
Sasaki, Hidenao
A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan
title A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan
title_full A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan
title_fullStr A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan
title_full_unstemmed A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan
title_short A Retrospective Epidemiological Study of Tick-Borne Encephalitis Virus in Patients with Neurological Disorders in Hokkaido, Japan
title_sort retrospective epidemiological study of tick-borne encephalitis virus in patients with neurological disorders in hokkaido, japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692117/
https://www.ncbi.nlm.nih.gov/pubmed/33126600
http://dx.doi.org/10.3390/microorganisms8111672
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