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MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers
Gastric cancer (GC) is one of the most common and difficult diseases to treat. The study of signaling pathway regulation by microRNA provides information on the mechanisms of GC development and is the basis for biomarker creation. In this study, a circuit of microRNA interactions with signaling path...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692123/ https://www.ncbi.nlm.nih.gov/pubmed/33142817 http://dx.doi.org/10.3390/diagnostics10110891 |
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author | Kipkeeva, Fatimat Muzaffarova, Tatyana Korotaeva, Alexandra Nikulin, Maxim Grishina, Kristina Mansorunov, Danzan Apanovich, Pavel Karpukhin, Alexander |
author_facet | Kipkeeva, Fatimat Muzaffarova, Tatyana Korotaeva, Alexandra Nikulin, Maxim Grishina, Kristina Mansorunov, Danzan Apanovich, Pavel Karpukhin, Alexander |
author_sort | Kipkeeva, Fatimat |
collection | PubMed |
description | Gastric cancer (GC) is one of the most common and difficult diseases to treat. The study of signaling pathway regulation by microRNA provides information on the mechanisms of GC development and is the basis for biomarker creation. In this study, a circuit of microRNA interactions with signaling pathways was constructed. The microRNAs, associated with metastasis and chemoresistance, are described. In most cases, microRNAs in GC regulate the Wnt/β-catenin, PI3K/AKT/mTOR, RAS/RAF/ERK/MAPK, NF-kB, TGF-β, and JAK/STAT pathways. Part of the microRNA acts on several target genes that function in different pathways. This often leads to an intensification of the induced processes. MicroRNAs have also been described that have the opposite effect on different pathways, causing different functional consequences. By acting on several target genes, or genes associated with several pathways, microRNAs can function in a signaling network. MicroRNAs associated with metastasis most often interact with the Wnt/β-catenin pathway. MicroRNAs affecting chemoresistance, in most cases, affect the regulators of apoptosis and are associated with the PI3K/AKT/mTOR pathway. The characteristics of microRNAs proposed as candidates for GC biomarkers were analyzed. The currently developed diagnostic and prognostic panels of microRNAs are also considered. |
format | Online Article Text |
id | pubmed-7692123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76921232020-11-28 MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers Kipkeeva, Fatimat Muzaffarova, Tatyana Korotaeva, Alexandra Nikulin, Maxim Grishina, Kristina Mansorunov, Danzan Apanovich, Pavel Karpukhin, Alexander Diagnostics (Basel) Review Gastric cancer (GC) is one of the most common and difficult diseases to treat. The study of signaling pathway regulation by microRNA provides information on the mechanisms of GC development and is the basis for biomarker creation. In this study, a circuit of microRNA interactions with signaling pathways was constructed. The microRNAs, associated with metastasis and chemoresistance, are described. In most cases, microRNAs in GC regulate the Wnt/β-catenin, PI3K/AKT/mTOR, RAS/RAF/ERK/MAPK, NF-kB, TGF-β, and JAK/STAT pathways. Part of the microRNA acts on several target genes that function in different pathways. This often leads to an intensification of the induced processes. MicroRNAs have also been described that have the opposite effect on different pathways, causing different functional consequences. By acting on several target genes, or genes associated with several pathways, microRNAs can function in a signaling network. MicroRNAs associated with metastasis most often interact with the Wnt/β-catenin pathway. MicroRNAs affecting chemoresistance, in most cases, affect the regulators of apoptosis and are associated with the PI3K/AKT/mTOR pathway. The characteristics of microRNAs proposed as candidates for GC biomarkers were analyzed. The currently developed diagnostic and prognostic panels of microRNAs are also considered. MDPI 2020-10-31 /pmc/articles/PMC7692123/ /pubmed/33142817 http://dx.doi.org/10.3390/diagnostics10110891 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kipkeeva, Fatimat Muzaffarova, Tatyana Korotaeva, Alexandra Nikulin, Maxim Grishina, Kristina Mansorunov, Danzan Apanovich, Pavel Karpukhin, Alexander MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers |
title | MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers |
title_full | MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers |
title_fullStr | MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers |
title_full_unstemmed | MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers |
title_short | MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers |
title_sort | microrna in gastric cancer development: mechanisms and biomarkers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692123/ https://www.ncbi.nlm.nih.gov/pubmed/33142817 http://dx.doi.org/10.3390/diagnostics10110891 |
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