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Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis
Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of strongyloidiasis in humans. Interestingly, HTLV-1 endemic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692131/ https://www.ncbi.nlm.nih.gov/pubmed/33137906 http://dx.doi.org/10.3390/pathogens9110904 |
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author | Dykie, Adam Wijesinghe, Tharaka Rabson, Arnold B. Madugula, Kiran Farinas, Christian Wilson, Sydney Abraham, David Jain, Pooja |
author_facet | Dykie, Adam Wijesinghe, Tharaka Rabson, Arnold B. Madugula, Kiran Farinas, Christian Wilson, Sydney Abraham, David Jain, Pooja |
author_sort | Dykie, Adam |
collection | PubMed |
description | Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of strongyloidiasis in humans. Interestingly, HTLV-1 endemic areas coincide with regions citing high prevalence of S. stercoralis infection, making these communities optimal for elucidating the pathogenesis of co-infection and its clinical significance. HTLV-1 co-infection with S. stercoralis has been observed for decades in a number of published patient cases and case series; however, the implications of this co-infection remain elusive. Thus far, data suggest that S. stercoralis increases proviral load in patients co-infected with HTLV-1 compared to HTLV-1 infection alone. Furthermore, co-infection with HTLV-1 has been associated with shifting the immune response from Th2 to Th1, affecting the ability of the immune system to address the helminth infection. Thus, despite this well-known association, further research is required to fully elucidate the impact of each pathogen on disease manifestations in co-infected patients. This review provides an analytical view of studies that have evaluated the variation within HTLV-1 patients in susceptibility to S. stercoralis infection, as well as the effects of strongyloidiasis on HTLV-1 pathogenesis. Further, it provides a compilation of available clinical reports on the epidemiology and pathology of HTLV-1 with parasitic co-infection as well as data from mechanistic studies suggesting possible immunopathogenic mechanisms. Furthermore, specific areas of potential future research have been highlighted to facilitate advancing understanding of the complex interactions between these two pathogens. |
format | Online Article Text |
id | pubmed-7692131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76921312020-11-28 Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis Dykie, Adam Wijesinghe, Tharaka Rabson, Arnold B. Madugula, Kiran Farinas, Christian Wilson, Sydney Abraham, David Jain, Pooja Pathogens Review Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of strongyloidiasis in humans. Interestingly, HTLV-1 endemic areas coincide with regions citing high prevalence of S. stercoralis infection, making these communities optimal for elucidating the pathogenesis of co-infection and its clinical significance. HTLV-1 co-infection with S. stercoralis has been observed for decades in a number of published patient cases and case series; however, the implications of this co-infection remain elusive. Thus far, data suggest that S. stercoralis increases proviral load in patients co-infected with HTLV-1 compared to HTLV-1 infection alone. Furthermore, co-infection with HTLV-1 has been associated with shifting the immune response from Th2 to Th1, affecting the ability of the immune system to address the helminth infection. Thus, despite this well-known association, further research is required to fully elucidate the impact of each pathogen on disease manifestations in co-infected patients. This review provides an analytical view of studies that have evaluated the variation within HTLV-1 patients in susceptibility to S. stercoralis infection, as well as the effects of strongyloidiasis on HTLV-1 pathogenesis. Further, it provides a compilation of available clinical reports on the epidemiology and pathology of HTLV-1 with parasitic co-infection as well as data from mechanistic studies suggesting possible immunopathogenic mechanisms. Furthermore, specific areas of potential future research have been highlighted to facilitate advancing understanding of the complex interactions between these two pathogens. MDPI 2020-10-29 /pmc/articles/PMC7692131/ /pubmed/33137906 http://dx.doi.org/10.3390/pathogens9110904 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dykie, Adam Wijesinghe, Tharaka Rabson, Arnold B. Madugula, Kiran Farinas, Christian Wilson, Sydney Abraham, David Jain, Pooja Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis |
title | Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis |
title_full | Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis |
title_fullStr | Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis |
title_full_unstemmed | Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis |
title_short | Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis |
title_sort | human t-cell leukemia virus type 1 and strongyloides stercoralis: partners in pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692131/ https://www.ncbi.nlm.nih.gov/pubmed/33137906 http://dx.doi.org/10.3390/pathogens9110904 |
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