Cargando…

Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background: Metabolic syndrome (MetS) increases the risk of cardiovascular disease, with atherogenic dyslipidemia being a major contributing factor. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to asses...

Descripción completa

Detalles Bibliográficos
Autores principales: AlAnouti, Fatme, Abboud, Myriam, Papandreou, Dimitrios, Mahboub, Nadine, Haidar, Suzan, Rizk, Rana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692169/
https://www.ncbi.nlm.nih.gov/pubmed/33143204
http://dx.doi.org/10.3390/nu12113352
_version_ 1783614449298440192
author AlAnouti, Fatme
Abboud, Myriam
Papandreou, Dimitrios
Mahboub, Nadine
Haidar, Suzan
Rizk, Rana
author_facet AlAnouti, Fatme
Abboud, Myriam
Papandreou, Dimitrios
Mahboub, Nadine
Haidar, Suzan
Rizk, Rana
author_sort AlAnouti, Fatme
collection PubMed
description Background: Metabolic syndrome (MetS) increases the risk of cardiovascular disease, with atherogenic dyslipidemia being a major contributing factor. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to assess whether vitamin D supplementation (VDS) alleviates dyslipidemia in adults with MetS. Scientific databases (PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, ClinicalTrials.gov, International Clinical Trials Registry Platform) and the gray literature were searched for randomized controlled trials of VDS, reporting on blood lipids. A narrative review, meta-analyses, sensitivity analyses, and appraisal of the risk of bias and overall quality of evidence produced were conducted. Results: Seven studies were included, and four were meta-analyzed. The risk of bias was generally low, and the final quality of evidence was low or very low. VDS, whether in high or low dose, significantly increased endline vitamin D blood levels; did not affect total, low-density, high-density cholesterol levels, and novel lipid-related biomarkers; yet, significantly increased triglycerides (TG) levels compared with placebo (MD: 30.67 (95%CI: 4.89–56.45) mg/dL; p = 0.02 for low-dose VDS; and MD: 27.33 (95%CI: 2.06–52.59) mg/dL; p = 0.03 for high-dose VDS). Pertaining heterogeneity was high (I(2) = 86%; and I(2) = 51%, respectively), and some included studies had significantly higher baseline TG in the intervention arm. The sensitivity analyses revealed robust results. Conclusion: VDS seems not to affect blood lipids in adults with MetS.
format Online
Article
Text
id pubmed-7692169
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76921692020-11-28 Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials AlAnouti, Fatme Abboud, Myriam Papandreou, Dimitrios Mahboub, Nadine Haidar, Suzan Rizk, Rana Nutrients Review Background: Metabolic syndrome (MetS) increases the risk of cardiovascular disease, with atherogenic dyslipidemia being a major contributing factor. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to assess whether vitamin D supplementation (VDS) alleviates dyslipidemia in adults with MetS. Scientific databases (PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, ClinicalTrials.gov, International Clinical Trials Registry Platform) and the gray literature were searched for randomized controlled trials of VDS, reporting on blood lipids. A narrative review, meta-analyses, sensitivity analyses, and appraisal of the risk of bias and overall quality of evidence produced were conducted. Results: Seven studies were included, and four were meta-analyzed. The risk of bias was generally low, and the final quality of evidence was low or very low. VDS, whether in high or low dose, significantly increased endline vitamin D blood levels; did not affect total, low-density, high-density cholesterol levels, and novel lipid-related biomarkers; yet, significantly increased triglycerides (TG) levels compared with placebo (MD: 30.67 (95%CI: 4.89–56.45) mg/dL; p = 0.02 for low-dose VDS; and MD: 27.33 (95%CI: 2.06–52.59) mg/dL; p = 0.03 for high-dose VDS). Pertaining heterogeneity was high (I(2) = 86%; and I(2) = 51%, respectively), and some included studies had significantly higher baseline TG in the intervention arm. The sensitivity analyses revealed robust results. Conclusion: VDS seems not to affect blood lipids in adults with MetS. MDPI 2020-10-30 /pmc/articles/PMC7692169/ /pubmed/33143204 http://dx.doi.org/10.3390/nu12113352 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
AlAnouti, Fatme
Abboud, Myriam
Papandreou, Dimitrios
Mahboub, Nadine
Haidar, Suzan
Rizk, Rana
Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_fullStr Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_short Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_sort effects of vitamin d supplementation on lipid profile in adults with the metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692169/
https://www.ncbi.nlm.nih.gov/pubmed/33143204
http://dx.doi.org/10.3390/nu12113352
work_keys_str_mv AT alanoutifatme effectsofvitamindsupplementationonlipidprofileinadultswiththemetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT abboudmyriam effectsofvitamindsupplementationonlipidprofileinadultswiththemetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT papandreoudimitrios effectsofvitamindsupplementationonlipidprofileinadultswiththemetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT mahboubnadine effectsofvitamindsupplementationonlipidprofileinadultswiththemetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT haidarsuzan effectsofvitamindsupplementationonlipidprofileinadultswiththemetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials
AT rizkrana effectsofvitamindsupplementationonlipidprofileinadultswiththemetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials