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The Regulatory Properties of the Ccr4–Not Complex

The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. In the nucleus, it is involved in the regulation of the cell cycle...

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Autores principales: Chalabi Hagkarim, Nafiseh, Grand, Roger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692201/
https://www.ncbi.nlm.nih.gov/pubmed/33138308
http://dx.doi.org/10.3390/cells9112379
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author Chalabi Hagkarim, Nafiseh
Grand, Roger J.
author_facet Chalabi Hagkarim, Nafiseh
Grand, Roger J.
author_sort Chalabi Hagkarim, Nafiseh
collection PubMed
description The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. In the nucleus, it is involved in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair. In the cytoplasm, the Ccr4–Not complex plays a central role in mRNA decay and affects protein quality control. Most of our original knowledge of the Ccr4–Not complex is derived, primarily, from studies in yeast. More recent studies have shown that the mammalian complex has a comparable structure and similar properties. In this review, we summarize the evidence for the multiple roles of both the yeast and mammalian Ccr4–Not complexes, highlighting their similarities.
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spelling pubmed-76922012020-11-28 The Regulatory Properties of the Ccr4–Not Complex Chalabi Hagkarim, Nafiseh Grand, Roger J. Cells Review The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. In the nucleus, it is involved in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair. In the cytoplasm, the Ccr4–Not complex plays a central role in mRNA decay and affects protein quality control. Most of our original knowledge of the Ccr4–Not complex is derived, primarily, from studies in yeast. More recent studies have shown that the mammalian complex has a comparable structure and similar properties. In this review, we summarize the evidence for the multiple roles of both the yeast and mammalian Ccr4–Not complexes, highlighting their similarities. MDPI 2020-10-29 /pmc/articles/PMC7692201/ /pubmed/33138308 http://dx.doi.org/10.3390/cells9112379 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chalabi Hagkarim, Nafiseh
Grand, Roger J.
The Regulatory Properties of the Ccr4–Not Complex
title The Regulatory Properties of the Ccr4–Not Complex
title_full The Regulatory Properties of the Ccr4–Not Complex
title_fullStr The Regulatory Properties of the Ccr4–Not Complex
title_full_unstemmed The Regulatory Properties of the Ccr4–Not Complex
title_short The Regulatory Properties of the Ccr4–Not Complex
title_sort regulatory properties of the ccr4–not complex
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692201/
https://www.ncbi.nlm.nih.gov/pubmed/33138308
http://dx.doi.org/10.3390/cells9112379
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