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Mediastinal Nodular Lesions Synchronous to Lung Carcinoma on Frozen Section: Trap and Lesson

Thymoma is the most frequent neoplasm arising in the anterior mediastum. It usually presents as an enlarged central mass. In the literature, multiple thymoma is described as an unusual finding; rare variants have also been described, like the signet ring-like cell variant. Evidence of co-existence o...

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Autores principales: Parente, Paola, Taurchini, Marco, Castelvetere, Marina, Di Micco, Concetta Martina, Greco, Domenico, Graziano, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692310/
https://www.ncbi.nlm.nih.gov/pubmed/33142919
http://dx.doi.org/10.3390/diagnostics10110893
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author Parente, Paola
Taurchini, Marco
Castelvetere, Marina
Di Micco, Concetta Martina
Greco, Domenico
Graziano, Paolo
author_facet Parente, Paola
Taurchini, Marco
Castelvetere, Marina
Di Micco, Concetta Martina
Greco, Domenico
Graziano, Paolo
author_sort Parente, Paola
collection PubMed
description Thymoma is the most frequent neoplasm arising in the anterior mediastum. It usually presents as an enlarged central mass. In the literature, multiple thymoma is described as an unusual finding; rare variants have also been described, like the signet ring-like cell variant. Evidence of co-existence of signet ring-like cells and lymphocytes in small biopsies from nodular mediastinal lesions can lead to a diagnosis of metastatic carcinoma, mostly at frozen sections. Thymoma and pulmonary carcinoma are very rarely associated neoplasms. We present a case of two mediastinal lesions discovered during pulmonary carcinoma staging. At frozen section, a diagnosis of ‘epithelioid proliferation associated to lymphoid tissue’ was advanced on a sample of nodular lesions and of ‘carcinoma’ on pulmonary biopsy. Double AB Type Thymoma with a signet ring cell-like component, synchronous to pulmonary adenocarcinoma, was the diagnosis made on formalin fixed-paraffin embedded samples. Reporting the coexistence of these two entities can help pathologists and surgeons to establish the best management of similar patients.
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spelling pubmed-76923102020-11-28 Mediastinal Nodular Lesions Synchronous to Lung Carcinoma on Frozen Section: Trap and Lesson Parente, Paola Taurchini, Marco Castelvetere, Marina Di Micco, Concetta Martina Greco, Domenico Graziano, Paolo Diagnostics (Basel) Case Report Thymoma is the most frequent neoplasm arising in the anterior mediastum. It usually presents as an enlarged central mass. In the literature, multiple thymoma is described as an unusual finding; rare variants have also been described, like the signet ring-like cell variant. Evidence of co-existence of signet ring-like cells and lymphocytes in small biopsies from nodular mediastinal lesions can lead to a diagnosis of metastatic carcinoma, mostly at frozen sections. Thymoma and pulmonary carcinoma are very rarely associated neoplasms. We present a case of two mediastinal lesions discovered during pulmonary carcinoma staging. At frozen section, a diagnosis of ‘epithelioid proliferation associated to lymphoid tissue’ was advanced on a sample of nodular lesions and of ‘carcinoma’ on pulmonary biopsy. Double AB Type Thymoma with a signet ring cell-like component, synchronous to pulmonary adenocarcinoma, was the diagnosis made on formalin fixed-paraffin embedded samples. Reporting the coexistence of these two entities can help pathologists and surgeons to establish the best management of similar patients. MDPI 2020-10-31 /pmc/articles/PMC7692310/ /pubmed/33142919 http://dx.doi.org/10.3390/diagnostics10110893 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Parente, Paola
Taurchini, Marco
Castelvetere, Marina
Di Micco, Concetta Martina
Greco, Domenico
Graziano, Paolo
Mediastinal Nodular Lesions Synchronous to Lung Carcinoma on Frozen Section: Trap and Lesson
title Mediastinal Nodular Lesions Synchronous to Lung Carcinoma on Frozen Section: Trap and Lesson
title_full Mediastinal Nodular Lesions Synchronous to Lung Carcinoma on Frozen Section: Trap and Lesson
title_fullStr Mediastinal Nodular Lesions Synchronous to Lung Carcinoma on Frozen Section: Trap and Lesson
title_full_unstemmed Mediastinal Nodular Lesions Synchronous to Lung Carcinoma on Frozen Section: Trap and Lesson
title_short Mediastinal Nodular Lesions Synchronous to Lung Carcinoma on Frozen Section: Trap and Lesson
title_sort mediastinal nodular lesions synchronous to lung carcinoma on frozen section: trap and lesson
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692310/
https://www.ncbi.nlm.nih.gov/pubmed/33142919
http://dx.doi.org/10.3390/diagnostics10110893
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