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Aminodextran Coated CoFe(2)O(4) Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia

Aminodextran (AMD) coated magnetic cobalt ferrite nanoparticles are synthesized via electrostatic adsorption of aminodextran onto magnetic nanoparticles and their potential theranostic application is evaluated. The uncoated and aminodextran-coated nanoparticles are characterized to determine their h...

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Autores principales: Khizar, Sumera, Ahmad, Nasir M., Ahmed, Naveed, Manzoor, Sadia, Hamayun, Muhammad A., Naseer, Nauman, Tenório, Michele K. L., Lebaz, Noureddine, Elaissari, Abdelhamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692372/
https://www.ncbi.nlm.nih.gov/pubmed/33147727
http://dx.doi.org/10.3390/nano10112182
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author Khizar, Sumera
Ahmad, Nasir M.
Ahmed, Naveed
Manzoor, Sadia
Hamayun, Muhammad A.
Naseer, Nauman
Tenório, Michele K. L.
Lebaz, Noureddine
Elaissari, Abdelhamid
author_facet Khizar, Sumera
Ahmad, Nasir M.
Ahmed, Naveed
Manzoor, Sadia
Hamayun, Muhammad A.
Naseer, Nauman
Tenório, Michele K. L.
Lebaz, Noureddine
Elaissari, Abdelhamid
author_sort Khizar, Sumera
collection PubMed
description Aminodextran (AMD) coated magnetic cobalt ferrite nanoparticles are synthesized via electrostatic adsorption of aminodextran onto magnetic nanoparticles and their potential theranostic application is evaluated. The uncoated and aminodextran-coated nanoparticles are characterized to determine their hydrodynamic size, morphology, chemical composition, zeta potential and magnetization. The aminodextran containing cobalt ferrite nanoparticles of nanometer size are positively charged in the pH range from 3 to 9 and exhibit saturation magnetization of 50 emu/g. The magnetic resonance imaging (MRI) indicates capability for diagnostics and a reduction in intensity with an increase in nanoparticle amount. The hyperthermia capability of the prepared particles shows their potential to generate suitable local heat for therapeutic purposes. There is a rise of 7 °C and 9 °C at 327 kHz and 981 kHz respectively and specific absorption rates (SAR) of aminodextran-coated nanoparticles are calculated to be 259 W/g and 518 W/g at the given frequencies larger than uncoated nanoparticles (0.02 W/g). The development of novel aminodextran coated magnetic cobalt ferrite nanoparticles has significant potential to enable and improve personalized therapy regimens, targeted cancer therapies and ultimately to overcome the prevalence of nonessential and overdosing of healthy tissues and organs.
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spelling pubmed-76923722020-11-28 Aminodextran Coated CoFe(2)O(4) Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia Khizar, Sumera Ahmad, Nasir M. Ahmed, Naveed Manzoor, Sadia Hamayun, Muhammad A. Naseer, Nauman Tenório, Michele K. L. Lebaz, Noureddine Elaissari, Abdelhamid Nanomaterials (Basel) Article Aminodextran (AMD) coated magnetic cobalt ferrite nanoparticles are synthesized via electrostatic adsorption of aminodextran onto magnetic nanoparticles and their potential theranostic application is evaluated. The uncoated and aminodextran-coated nanoparticles are characterized to determine their hydrodynamic size, morphology, chemical composition, zeta potential and magnetization. The aminodextran containing cobalt ferrite nanoparticles of nanometer size are positively charged in the pH range from 3 to 9 and exhibit saturation magnetization of 50 emu/g. The magnetic resonance imaging (MRI) indicates capability for diagnostics and a reduction in intensity with an increase in nanoparticle amount. The hyperthermia capability of the prepared particles shows their potential to generate suitable local heat for therapeutic purposes. There is a rise of 7 °C and 9 °C at 327 kHz and 981 kHz respectively and specific absorption rates (SAR) of aminodextran-coated nanoparticles are calculated to be 259 W/g and 518 W/g at the given frequencies larger than uncoated nanoparticles (0.02 W/g). The development of novel aminodextran coated magnetic cobalt ferrite nanoparticles has significant potential to enable and improve personalized therapy regimens, targeted cancer therapies and ultimately to overcome the prevalence of nonessential and overdosing of healthy tissues and organs. MDPI 2020-11-02 /pmc/articles/PMC7692372/ /pubmed/33147727 http://dx.doi.org/10.3390/nano10112182 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khizar, Sumera
Ahmad, Nasir M.
Ahmed, Naveed
Manzoor, Sadia
Hamayun, Muhammad A.
Naseer, Nauman
Tenório, Michele K. L.
Lebaz, Noureddine
Elaissari, Abdelhamid
Aminodextran Coated CoFe(2)O(4) Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia
title Aminodextran Coated CoFe(2)O(4) Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia
title_full Aminodextran Coated CoFe(2)O(4) Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia
title_fullStr Aminodextran Coated CoFe(2)O(4) Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia
title_full_unstemmed Aminodextran Coated CoFe(2)O(4) Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia
title_short Aminodextran Coated CoFe(2)O(4) Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia
title_sort aminodextran coated cofe(2)o(4) nanoparticles for combined magnetic resonance imaging and hyperthermia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692372/
https://www.ncbi.nlm.nih.gov/pubmed/33147727
http://dx.doi.org/10.3390/nano10112182
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