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Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19

This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil,...

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Autores principales: de Dios, Elena, Rios-Navarro, Cesar, Perez-Sole, Nerea, Gavara, Jose, Marcos-Garces, Victor, Rodríguez, Enrique, Carratalá, Arturo, Forner, Maria J., Navarro, Jorge, Blasco, Maria L., Bondia, Elvira, Signes-Costa, Jaime, Vila, Jose M., Forteza, Maria J., Chorro, Francisco J., Bodi, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692467/
https://www.ncbi.nlm.nih.gov/pubmed/33126723
http://dx.doi.org/10.3390/jcm9113484
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author de Dios, Elena
Rios-Navarro, Cesar
Perez-Sole, Nerea
Gavara, Jose
Marcos-Garces, Victor
Rodríguez, Enrique
Carratalá, Arturo
Forner, Maria J.
Navarro, Jorge
Blasco, Maria L.
Bondia, Elvira
Signes-Costa, Jaime
Vila, Jose M.
Forteza, Maria J.
Chorro, Francisco J.
Bodi, Vicente
author_facet de Dios, Elena
Rios-Navarro, Cesar
Perez-Sole, Nerea
Gavara, Jose
Marcos-Garces, Victor
Rodríguez, Enrique
Carratalá, Arturo
Forner, Maria J.
Navarro, Jorge
Blasco, Maria L.
Bondia, Elvira
Signes-Costa, Jaime
Vila, Jose M.
Forteza, Maria J.
Chorro, Francisco J.
Bodi, Vicente
author_sort de Dios, Elena
collection PubMed
description This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil, lymphocyte and NLR were sequentially measured in 659 patients admitted for STEMI and in 103 COVID-19 patients. The dynamics detected in STEMI (within a few hours) were replicated in COVID-19 (within a few days). In both entities patients with events and with severe structural damage displayed higher neutrophil and lower lymphocyte counts. In both scenarios, higher maximum neutrophil and lower minimum lymphocyte counts were associated with more events and more severe organ damage. NLR was higher in STEMI and COVID-19 patients with the worst clinical and structural outcomes. A canonical deregulation of the immune response occurs in STEMI and COVID-19 patients. Boosted circulating innate (neutrophilia) and depressed circulating adaptive immunity (lymphopenia) is associated with more events and severe organ damage. A greater understanding of these critical illnesses is pivotal to explore novel alternative therapies.
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spelling pubmed-76924672020-11-28 Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19 de Dios, Elena Rios-Navarro, Cesar Perez-Sole, Nerea Gavara, Jose Marcos-Garces, Victor Rodríguez, Enrique Carratalá, Arturo Forner, Maria J. Navarro, Jorge Blasco, Maria L. Bondia, Elvira Signes-Costa, Jaime Vila, Jose M. Forteza, Maria J. Chorro, Francisco J. Bodi, Vicente J Clin Med Article This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil, lymphocyte and NLR were sequentially measured in 659 patients admitted for STEMI and in 103 COVID-19 patients. The dynamics detected in STEMI (within a few hours) were replicated in COVID-19 (within a few days). In both entities patients with events and with severe structural damage displayed higher neutrophil and lower lymphocyte counts. In both scenarios, higher maximum neutrophil and lower minimum lymphocyte counts were associated with more events and more severe organ damage. NLR was higher in STEMI and COVID-19 patients with the worst clinical and structural outcomes. A canonical deregulation of the immune response occurs in STEMI and COVID-19 patients. Boosted circulating innate (neutrophilia) and depressed circulating adaptive immunity (lymphopenia) is associated with more events and severe organ damage. A greater understanding of these critical illnesses is pivotal to explore novel alternative therapies. MDPI 2020-10-28 /pmc/articles/PMC7692467/ /pubmed/33126723 http://dx.doi.org/10.3390/jcm9113484 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Dios, Elena
Rios-Navarro, Cesar
Perez-Sole, Nerea
Gavara, Jose
Marcos-Garces, Victor
Rodríguez, Enrique
Carratalá, Arturo
Forner, Maria J.
Navarro, Jorge
Blasco, Maria L.
Bondia, Elvira
Signes-Costa, Jaime
Vila, Jose M.
Forteza, Maria J.
Chorro, Francisco J.
Bodi, Vicente
Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19
title Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19
title_full Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19
title_fullStr Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19
title_full_unstemmed Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19
title_short Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19
title_sort similar clinical course and significance of circulating innate and adaptive immune cell counts in stemi and covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692467/
https://www.ncbi.nlm.nih.gov/pubmed/33126723
http://dx.doi.org/10.3390/jcm9113484
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