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Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS)
Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultras...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692482/ https://www.ncbi.nlm.nih.gov/pubmed/33244180 http://dx.doi.org/10.1038/s41598-020-77801-9 |
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author | Chang, Johannes Dumitrache, Alexia Böhling, Nina Abu-Omar, Jasmin Meyer, Carsten Strobel, Deike Luetkens, Julian Luu, Andreas Minh Rockstroh, Jürgen Strassburg, Christian P. Trebicka, Jonel Gonzalez-Carmona, Maria A. Marinova, Milka Praktiknjo, Michael |
author_facet | Chang, Johannes Dumitrache, Alexia Böhling, Nina Abu-Omar, Jasmin Meyer, Carsten Strobel, Deike Luetkens, Julian Luu, Andreas Minh Rockstroh, Jürgen Strassburg, Christian P. Trebicka, Jonel Gonzalez-Carmona, Maria A. Marinova, Milka Praktiknjo, Michael |
author_sort | Chang, Johannes |
collection | PubMed |
description | Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultrasound (CEUS) to diagnose hepatocellular carcinoma (HCC) in cirrhosis with TIPS. In this prospective monocentric observational study, CEUS was used to characterize focal liver lesions in patients at risk for HCC with and without TIPS. Times of arterial phase hyperenhancement (APHE) und washout were quantified. Perfusion-index (PI) and resistance-index (RI) of hepatic artery and portal venous flow parameters were measured via doppler ultrasonography. Diagnostic gold standard was MRI/CT or histology. This study included 49 liver lesions [23 TIPS (11 HCC), 26 no TIPS (15 HCC)]. 26 were diagnosed as HCC by gold standard. Sensitivity and specificity of CEUS to diagnose HCC with and without TIPS were 93.3% and 100% vs. 90.9% and 93.3%, respectively. APHE appeared significantly earlier in patients with TIPS compared to patients without TIPS. TIPS significantly accentuates APHE of HCC in CEUS. CEUS has good diagnostic performance for diagnosis of HCC in patients with TIPS. |
format | Online Article Text |
id | pubmed-7692482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76924822020-11-30 Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS) Chang, Johannes Dumitrache, Alexia Böhling, Nina Abu-Omar, Jasmin Meyer, Carsten Strobel, Deike Luetkens, Julian Luu, Andreas Minh Rockstroh, Jürgen Strassburg, Christian P. Trebicka, Jonel Gonzalez-Carmona, Maria A. Marinova, Milka Praktiknjo, Michael Sci Rep Article Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultrasound (CEUS) to diagnose hepatocellular carcinoma (HCC) in cirrhosis with TIPS. In this prospective monocentric observational study, CEUS was used to characterize focal liver lesions in patients at risk for HCC with and without TIPS. Times of arterial phase hyperenhancement (APHE) und washout were quantified. Perfusion-index (PI) and resistance-index (RI) of hepatic artery and portal venous flow parameters were measured via doppler ultrasonography. Diagnostic gold standard was MRI/CT or histology. This study included 49 liver lesions [23 TIPS (11 HCC), 26 no TIPS (15 HCC)]. 26 were diagnosed as HCC by gold standard. Sensitivity and specificity of CEUS to diagnose HCC with and without TIPS were 93.3% and 100% vs. 90.9% and 93.3%, respectively. APHE appeared significantly earlier in patients with TIPS compared to patients without TIPS. TIPS significantly accentuates APHE of HCC in CEUS. CEUS has good diagnostic performance for diagnosis of HCC in patients with TIPS. Nature Publishing Group UK 2020-11-26 /pmc/articles/PMC7692482/ /pubmed/33244180 http://dx.doi.org/10.1038/s41598-020-77801-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chang, Johannes Dumitrache, Alexia Böhling, Nina Abu-Omar, Jasmin Meyer, Carsten Strobel, Deike Luetkens, Julian Luu, Andreas Minh Rockstroh, Jürgen Strassburg, Christian P. Trebicka, Jonel Gonzalez-Carmona, Maria A. Marinova, Milka Praktiknjo, Michael Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS) |
title | Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS) |
title_full | Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS) |
title_fullStr | Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS) |
title_full_unstemmed | Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS) |
title_short | Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS) |
title_sort | alteration of contrast enhanced ultrasound (ceus) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (tips) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692482/ https://www.ncbi.nlm.nih.gov/pubmed/33244180 http://dx.doi.org/10.1038/s41598-020-77801-9 |
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