Cargando…

Pyrethroids: How They Affect Human and Animal Health?

Pyrethroids are pesticides commonly used in crop protection; in the forestry, wood, and textile industries; as well as in medicine and veterinary medicine to treat parasitic crustacean infestations. They have been found to be relatively safe for humans and animals. Pyrethroids are recommended for pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Hołyńska-Iwan, Iga, Szewczyk-Golec, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692614/
https://www.ncbi.nlm.nih.gov/pubmed/33143129
http://dx.doi.org/10.3390/medicina56110582
_version_ 1783614553092784128
author Hołyńska-Iwan, Iga
Szewczyk-Golec, Karolina
author_facet Hołyńska-Iwan, Iga
Szewczyk-Golec, Karolina
author_sort Hołyńska-Iwan, Iga
collection PubMed
description Pyrethroids are pesticides commonly used in crop protection; in the forestry, wood, and textile industries; as well as in medicine and veterinary medicine to treat parasitic crustacean infestations. They have been found to be relatively safe for humans and animals. Pyrethroids are recommended for personal protection against malaria and virus Zika by the World Health Organization. Pyrethroids act on voltage-gated sodium channels, which cause an influx of sodium ions into the nerve cells and permanent depolarization. They also influence activities of enzymes, especially in nerve and liver cells. Contact of pyrethroids with the skin, digestive tract, and respiratory tract results in their penetration into the body. Due to the importance of the subject, a summary of the current state of knowledge on the toxic effects of pyrethroids was presented in the comprehensive review by Chrustek et al, published in journal Medicina. Particular attention was paid to nephrotoxic, hepatotoxic, cardiotoxic, immunotoxic, neurotoxic, and behavioral effects of pyrethroids on human and animal bodies. It could be added that pyrethroids generate oxidative stress, which modifies DNA, RNA, protein, lipid and carbohydrate molecules. However, public awareness of the possible negative effects of the use of insecticides is still low. Further research should be carried out to clarify the molecular basis of the pathomechanism of pyrethroid detrimental action. Proper dissemination of the results seems to be of first importance for public health.
format Online
Article
Text
id pubmed-7692614
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76926142020-11-28 Pyrethroids: How They Affect Human and Animal Health? Hołyńska-Iwan, Iga Szewczyk-Golec, Karolina Medicina (Kaunas) Editorial Pyrethroids are pesticides commonly used in crop protection; in the forestry, wood, and textile industries; as well as in medicine and veterinary medicine to treat parasitic crustacean infestations. They have been found to be relatively safe for humans and animals. Pyrethroids are recommended for personal protection against malaria and virus Zika by the World Health Organization. Pyrethroids act on voltage-gated sodium channels, which cause an influx of sodium ions into the nerve cells and permanent depolarization. They also influence activities of enzymes, especially in nerve and liver cells. Contact of pyrethroids with the skin, digestive tract, and respiratory tract results in their penetration into the body. Due to the importance of the subject, a summary of the current state of knowledge on the toxic effects of pyrethroids was presented in the comprehensive review by Chrustek et al, published in journal Medicina. Particular attention was paid to nephrotoxic, hepatotoxic, cardiotoxic, immunotoxic, neurotoxic, and behavioral effects of pyrethroids on human and animal bodies. It could be added that pyrethroids generate oxidative stress, which modifies DNA, RNA, protein, lipid and carbohydrate molecules. However, public awareness of the possible negative effects of the use of insecticides is still low. Further research should be carried out to clarify the molecular basis of the pathomechanism of pyrethroid detrimental action. Proper dissemination of the results seems to be of first importance for public health. MDPI 2020-10-30 /pmc/articles/PMC7692614/ /pubmed/33143129 http://dx.doi.org/10.3390/medicina56110582 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Hołyńska-Iwan, Iga
Szewczyk-Golec, Karolina
Pyrethroids: How They Affect Human and Animal Health?
title Pyrethroids: How They Affect Human and Animal Health?
title_full Pyrethroids: How They Affect Human and Animal Health?
title_fullStr Pyrethroids: How They Affect Human and Animal Health?
title_full_unstemmed Pyrethroids: How They Affect Human and Animal Health?
title_short Pyrethroids: How They Affect Human and Animal Health?
title_sort pyrethroids: how they affect human and animal health?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692614/
https://www.ncbi.nlm.nih.gov/pubmed/33143129
http://dx.doi.org/10.3390/medicina56110582
work_keys_str_mv AT hołynskaiwaniga pyrethroidshowtheyaffecthumanandanimalhealth
AT szewczykgoleckarolina pyrethroidshowtheyaffecthumanandanimalhealth