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Pyrethroids: How They Affect Human and Animal Health?
Pyrethroids are pesticides commonly used in crop protection; in the forestry, wood, and textile industries; as well as in medicine and veterinary medicine to treat parasitic crustacean infestations. They have been found to be relatively safe for humans and animals. Pyrethroids are recommended for pe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692614/ https://www.ncbi.nlm.nih.gov/pubmed/33143129 http://dx.doi.org/10.3390/medicina56110582 |
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author | Hołyńska-Iwan, Iga Szewczyk-Golec, Karolina |
author_facet | Hołyńska-Iwan, Iga Szewczyk-Golec, Karolina |
author_sort | Hołyńska-Iwan, Iga |
collection | PubMed |
description | Pyrethroids are pesticides commonly used in crop protection; in the forestry, wood, and textile industries; as well as in medicine and veterinary medicine to treat parasitic crustacean infestations. They have been found to be relatively safe for humans and animals. Pyrethroids are recommended for personal protection against malaria and virus Zika by the World Health Organization. Pyrethroids act on voltage-gated sodium channels, which cause an influx of sodium ions into the nerve cells and permanent depolarization. They also influence activities of enzymes, especially in nerve and liver cells. Contact of pyrethroids with the skin, digestive tract, and respiratory tract results in their penetration into the body. Due to the importance of the subject, a summary of the current state of knowledge on the toxic effects of pyrethroids was presented in the comprehensive review by Chrustek et al, published in journal Medicina. Particular attention was paid to nephrotoxic, hepatotoxic, cardiotoxic, immunotoxic, neurotoxic, and behavioral effects of pyrethroids on human and animal bodies. It could be added that pyrethroids generate oxidative stress, which modifies DNA, RNA, protein, lipid and carbohydrate molecules. However, public awareness of the possible negative effects of the use of insecticides is still low. Further research should be carried out to clarify the molecular basis of the pathomechanism of pyrethroid detrimental action. Proper dissemination of the results seems to be of first importance for public health. |
format | Online Article Text |
id | pubmed-7692614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76926142020-11-28 Pyrethroids: How They Affect Human and Animal Health? Hołyńska-Iwan, Iga Szewczyk-Golec, Karolina Medicina (Kaunas) Editorial Pyrethroids are pesticides commonly used in crop protection; in the forestry, wood, and textile industries; as well as in medicine and veterinary medicine to treat parasitic crustacean infestations. They have been found to be relatively safe for humans and animals. Pyrethroids are recommended for personal protection against malaria and virus Zika by the World Health Organization. Pyrethroids act on voltage-gated sodium channels, which cause an influx of sodium ions into the nerve cells and permanent depolarization. They also influence activities of enzymes, especially in nerve and liver cells. Contact of pyrethroids with the skin, digestive tract, and respiratory tract results in their penetration into the body. Due to the importance of the subject, a summary of the current state of knowledge on the toxic effects of pyrethroids was presented in the comprehensive review by Chrustek et al, published in journal Medicina. Particular attention was paid to nephrotoxic, hepatotoxic, cardiotoxic, immunotoxic, neurotoxic, and behavioral effects of pyrethroids on human and animal bodies. It could be added that pyrethroids generate oxidative stress, which modifies DNA, RNA, protein, lipid and carbohydrate molecules. However, public awareness of the possible negative effects of the use of insecticides is still low. Further research should be carried out to clarify the molecular basis of the pathomechanism of pyrethroid detrimental action. Proper dissemination of the results seems to be of first importance for public health. MDPI 2020-10-30 /pmc/articles/PMC7692614/ /pubmed/33143129 http://dx.doi.org/10.3390/medicina56110582 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Hołyńska-Iwan, Iga Szewczyk-Golec, Karolina Pyrethroids: How They Affect Human and Animal Health? |
title | Pyrethroids: How They Affect Human and Animal Health? |
title_full | Pyrethroids: How They Affect Human and Animal Health? |
title_fullStr | Pyrethroids: How They Affect Human and Animal Health? |
title_full_unstemmed | Pyrethroids: How They Affect Human and Animal Health? |
title_short | Pyrethroids: How They Affect Human and Animal Health? |
title_sort | pyrethroids: how they affect human and animal health? |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692614/ https://www.ncbi.nlm.nih.gov/pubmed/33143129 http://dx.doi.org/10.3390/medicina56110582 |
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