IGF1R and MAPK15 Emerge as Potential Targets of Pentabromobenzylisothioureas in Lung Neuroendocrine Neoplasms

Pentabromobenzylisothioureas are antitumor agents with diverse properties, including the inhibition of MAPK15, IGF1R and PKD1 kinases. Their dysregulation has been implicated in the pathogenesis of several cancers, including bronchopulmonary neuroendocrine neoplasms (BP-NEN). The present study asses...

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Detalles Bibliográficos
Autores principales: Motylewska, Ewelina, Braun, Marcin, Kazimierczuk, Zygmunt, Ławnicka, Hanna, Stępień, Henryk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692632/
https://www.ncbi.nlm.nih.gov/pubmed/33138224
http://dx.doi.org/10.3390/ph13110354

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