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Long‐Term Colloidally Stable Aqueous Dispersions of ≤5 nm Spinel Ferrite Nanoparticles

Applications in biomedicine and ferrofluids, for instance, require long‐term colloidally stable, concentrated aqueous dispersions of magnetic, biocompatible nanoparticles. Iron oxide and related spinel ferrite nanoparticles stabilized with organic molecules allow fine‐tuning of magnetic properties v...

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Detalles Bibliográficos
Autores principales: Eckardt, Mirco, Thomä, Sabrina L. J., Dulle, Martin, Hörner, Gerald, Weber, Birgit, Förster, Stefan, Zobel, Mirijam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692645/
https://www.ncbi.nlm.nih.gov/pubmed/33294306
http://dx.doi.org/10.1002/open.202000313
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author Eckardt, Mirco
Thomä, Sabrina L. J.
Dulle, Martin
Hörner, Gerald
Weber, Birgit
Förster, Stefan
Zobel, Mirijam
author_facet Eckardt, Mirco
Thomä, Sabrina L. J.
Dulle, Martin
Hörner, Gerald
Weber, Birgit
Förster, Stefan
Zobel, Mirijam
author_sort Eckardt, Mirco
collection PubMed
description Applications in biomedicine and ferrofluids, for instance, require long‐term colloidally stable, concentrated aqueous dispersions of magnetic, biocompatible nanoparticles. Iron oxide and related spinel ferrite nanoparticles stabilized with organic molecules allow fine‐tuning of magnetic properties via cation substitution and water‐dispersibility. Here, we synthesize≤5 nm iron oxide and spinel ferrite nanoparticles, capped with citrate, betaine and phosphocholine, in a one‐pot strategy. We present a robust approach combining elemental (CHN) and thermal gravimetric analysis (TGA) to quantify the ratio of residual solvent molecules and organic stabilizers on the particle surface, being of particular accuracy for ligands with heteroatoms compared to the solvent. SAXS experiments demonstrate the long‐term colloidal stability of our aqueous iron oxide and spinel ferrite nanoparticle dispersions for at least 3 months. By the use of SAXS we approved directly the colloidal stability of the nanoparticle dispersions for high concentrations up to 100 g L(−1).
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spelling pubmed-76926452020-12-07 Long‐Term Colloidally Stable Aqueous Dispersions of ≤5 nm Spinel Ferrite Nanoparticles Eckardt, Mirco Thomä, Sabrina L. J. Dulle, Martin Hörner, Gerald Weber, Birgit Förster, Stefan Zobel, Mirijam ChemistryOpen Full Papers Applications in biomedicine and ferrofluids, for instance, require long‐term colloidally stable, concentrated aqueous dispersions of magnetic, biocompatible nanoparticles. Iron oxide and related spinel ferrite nanoparticles stabilized with organic molecules allow fine‐tuning of magnetic properties via cation substitution and water‐dispersibility. Here, we synthesize≤5 nm iron oxide and spinel ferrite nanoparticles, capped with citrate, betaine and phosphocholine, in a one‐pot strategy. We present a robust approach combining elemental (CHN) and thermal gravimetric analysis (TGA) to quantify the ratio of residual solvent molecules and organic stabilizers on the particle surface, being of particular accuracy for ligands with heteroatoms compared to the solvent. SAXS experiments demonstrate the long‐term colloidal stability of our aqueous iron oxide and spinel ferrite nanoparticle dispersions for at least 3 months. By the use of SAXS we approved directly the colloidal stability of the nanoparticle dispersions for high concentrations up to 100 g L(−1). John Wiley and Sons Inc. 2020-11-27 /pmc/articles/PMC7692645/ /pubmed/33294306 http://dx.doi.org/10.1002/open.202000313 Text en © 2020 The Authors. Published by The Chemical Society of Japan & Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Full Papers
Eckardt, Mirco
Thomä, Sabrina L. J.
Dulle, Martin
Hörner, Gerald
Weber, Birgit
Förster, Stefan
Zobel, Mirijam
Long‐Term Colloidally Stable Aqueous Dispersions of ≤5 nm Spinel Ferrite Nanoparticles
title Long‐Term Colloidally Stable Aqueous Dispersions of ≤5 nm Spinel Ferrite Nanoparticles
title_full Long‐Term Colloidally Stable Aqueous Dispersions of ≤5 nm Spinel Ferrite Nanoparticles
title_fullStr Long‐Term Colloidally Stable Aqueous Dispersions of ≤5 nm Spinel Ferrite Nanoparticles
title_full_unstemmed Long‐Term Colloidally Stable Aqueous Dispersions of ≤5 nm Spinel Ferrite Nanoparticles
title_short Long‐Term Colloidally Stable Aqueous Dispersions of ≤5 nm Spinel Ferrite Nanoparticles
title_sort long‐term colloidally stable aqueous dispersions of ≤5 nm spinel ferrite nanoparticles
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692645/
https://www.ncbi.nlm.nih.gov/pubmed/33294306
http://dx.doi.org/10.1002/open.202000313
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