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Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI. We examined a novel hypothesis: caspase 1 and caspase 11 serve as danger-associated molecular pattern (DAMPs) sensors in I...

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Detalles Bibliográficos
Autores principales:	Fagenson, Alexander M., Xu, Keman, Saaoud, Fatma, Nanayakkara, Gayani, Jhala, Nirag C., Liu, Lu, Drummer, Charles, Sun, Yu, Lau, Kwan N., Di Carlo, Antonio, Jiang, Xiaohua, Wang, Hong, Karhadkar, Sunil S., Yang, Xiaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692674/ https://www.ncbi.nlm.nih.gov/pubmed/33114395 http://dx.doi.org/10.3390/pathogens9110879

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