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Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress

Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding,...

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Autores principales: Diz-Chaves, Yolanda, Herrera-Pérez, Salvador, González-Matías, Lucas C., Lamas, José Antonio, Mallo, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692797/
https://www.ncbi.nlm.nih.gov/pubmed/33126672
http://dx.doi.org/10.3390/nu12113304
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author Diz-Chaves, Yolanda
Herrera-Pérez, Salvador
González-Matías, Lucas C.
Lamas, José Antonio
Mallo, Federico
author_facet Diz-Chaves, Yolanda
Herrera-Pérez, Salvador
González-Matías, Lucas C.
Lamas, José Antonio
Mallo, Federico
author_sort Diz-Chaves, Yolanda
collection PubMed
description Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding, and the motivation to feed or regulate the stress response and the hypothalamic-pituitary-adrenal axis. GLP-1 receptor (GLP-1R) controls both food intake and feeding behavior (hunger-driven feeding, the hedonic value of food, and food motivation). The activation of GLP-1 receptors involves second messenger pathways and ionic events in the autonomic nervous system, which are very relevant to explain the essential central actions of GLP-1 as neuromodulator coordinating food intake in response to a physiological and stress-related stimulus to maintain homeostasis. Alterations in GLP-1 signaling associated with obesity or chronic stress induce the dysregulation of eating behavior. This review summarized the experimental shreds of evidence from studies using GLP-1R agonists to describe the neural and endocrine integration of stress responses and feeding behavior.
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spelling pubmed-76927972020-11-28 Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress Diz-Chaves, Yolanda Herrera-Pérez, Salvador González-Matías, Lucas C. Lamas, José Antonio Mallo, Federico Nutrients Review Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding, and the motivation to feed or regulate the stress response and the hypothalamic-pituitary-adrenal axis. GLP-1 receptor (GLP-1R) controls both food intake and feeding behavior (hunger-driven feeding, the hedonic value of food, and food motivation). The activation of GLP-1 receptors involves second messenger pathways and ionic events in the autonomic nervous system, which are very relevant to explain the essential central actions of GLP-1 as neuromodulator coordinating food intake in response to a physiological and stress-related stimulus to maintain homeostasis. Alterations in GLP-1 signaling associated with obesity or chronic stress induce the dysregulation of eating behavior. This review summarized the experimental shreds of evidence from studies using GLP-1R agonists to describe the neural and endocrine integration of stress responses and feeding behavior. MDPI 2020-10-28 /pmc/articles/PMC7692797/ /pubmed/33126672 http://dx.doi.org/10.3390/nu12113304 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diz-Chaves, Yolanda
Herrera-Pérez, Salvador
González-Matías, Lucas C.
Lamas, José Antonio
Mallo, Federico
Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
title Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
title_full Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
title_fullStr Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
title_full_unstemmed Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
title_short Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
title_sort glucagon-like peptide-1 (glp-1) in the integration of neural and endocrine responses to stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692797/
https://www.ncbi.nlm.nih.gov/pubmed/33126672
http://dx.doi.org/10.3390/nu12113304
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