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Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692797/ https://www.ncbi.nlm.nih.gov/pubmed/33126672 http://dx.doi.org/10.3390/nu12113304 |
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author | Diz-Chaves, Yolanda Herrera-Pérez, Salvador González-Matías, Lucas C. Lamas, José Antonio Mallo, Federico |
author_facet | Diz-Chaves, Yolanda Herrera-Pérez, Salvador González-Matías, Lucas C. Lamas, José Antonio Mallo, Federico |
author_sort | Diz-Chaves, Yolanda |
collection | PubMed |
description | Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding, and the motivation to feed or regulate the stress response and the hypothalamic-pituitary-adrenal axis. GLP-1 receptor (GLP-1R) controls both food intake and feeding behavior (hunger-driven feeding, the hedonic value of food, and food motivation). The activation of GLP-1 receptors involves second messenger pathways and ionic events in the autonomic nervous system, which are very relevant to explain the essential central actions of GLP-1 as neuromodulator coordinating food intake in response to a physiological and stress-related stimulus to maintain homeostasis. Alterations in GLP-1 signaling associated with obesity or chronic stress induce the dysregulation of eating behavior. This review summarized the experimental shreds of evidence from studies using GLP-1R agonists to describe the neural and endocrine integration of stress responses and feeding behavior. |
format | Online Article Text |
id | pubmed-7692797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76927972020-11-28 Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress Diz-Chaves, Yolanda Herrera-Pérez, Salvador González-Matías, Lucas C. Lamas, José Antonio Mallo, Federico Nutrients Review Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding, and the motivation to feed or regulate the stress response and the hypothalamic-pituitary-adrenal axis. GLP-1 receptor (GLP-1R) controls both food intake and feeding behavior (hunger-driven feeding, the hedonic value of food, and food motivation). The activation of GLP-1 receptors involves second messenger pathways and ionic events in the autonomic nervous system, which are very relevant to explain the essential central actions of GLP-1 as neuromodulator coordinating food intake in response to a physiological and stress-related stimulus to maintain homeostasis. Alterations in GLP-1 signaling associated with obesity or chronic stress induce the dysregulation of eating behavior. This review summarized the experimental shreds of evidence from studies using GLP-1R agonists to describe the neural and endocrine integration of stress responses and feeding behavior. MDPI 2020-10-28 /pmc/articles/PMC7692797/ /pubmed/33126672 http://dx.doi.org/10.3390/nu12113304 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Diz-Chaves, Yolanda Herrera-Pérez, Salvador González-Matías, Lucas C. Lamas, José Antonio Mallo, Federico Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress |
title | Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress |
title_full | Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress |
title_fullStr | Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress |
title_full_unstemmed | Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress |
title_short | Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress |
title_sort | glucagon-like peptide-1 (glp-1) in the integration of neural and endocrine responses to stress |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692797/ https://www.ncbi.nlm.nih.gov/pubmed/33126672 http://dx.doi.org/10.3390/nu12113304 |
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