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Prevalence and Outcomes of Acute Hypoxaemic Respiratory Failure in Wales: The PANDORA-WALES Study
Background: We aimed to identify the prevalence of acute hypoxaemic respiratory failure (AHRF) in the intensive care unit (ICU) and its associated mortality. The secondary aim was to describe ventilatory management as well as the use of rescue therapies. Methods: Multi-centre prospective study in ni...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692809/ https://www.ncbi.nlm.nih.gov/pubmed/33142837 http://dx.doi.org/10.3390/jcm9113521 |
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author | Kopczynska, Maja Sharif, Ben Pugh, Richard Otahal, Igor Havalda, Peter Groblewski, Wojciech Lynch, Ceri George, David Sutherland, Jayne Pandey, Manish Jones, Phillippa Murdoch, Maxene Hatalyak, Adam Jones, Rhidian Kacmarek, Robert M. Villar, Jesús Szakmany, Tamas |
author_facet | Kopczynska, Maja Sharif, Ben Pugh, Richard Otahal, Igor Havalda, Peter Groblewski, Wojciech Lynch, Ceri George, David Sutherland, Jayne Pandey, Manish Jones, Phillippa Murdoch, Maxene Hatalyak, Adam Jones, Rhidian Kacmarek, Robert M. Villar, Jesús Szakmany, Tamas |
author_sort | Kopczynska, Maja |
collection | PubMed |
description | Background: We aimed to identify the prevalence of acute hypoxaemic respiratory failure (AHRF) in the intensive care unit (ICU) and its associated mortality. The secondary aim was to describe ventilatory management as well as the use of rescue therapies. Methods: Multi-centre prospective study in nine hospitals in Wales, UK, over 2-month periods. All patients admitted to an ICU were screened for AHRF and followed-up until discharge from the ICU. Data were collected from patient charts on patient demographics, clinical characteristics, management and outcomes. Results: Out of 2215 critical care admissions, 886 patients received mechanical ventilation. A total of 197 patients met inclusion criteria and were recruited. Seventy (35.5%) were non-survivors. Non-survivors were significantly older, had higher SOFA scores and received more vasopressor support than survivors. Twenty-five (12.7%) patients who fulfilled the Berlin definition of acute respiratory distress syndrome (ARDS) during the ICU stay without impact on overall survival. Rescue therapies were rarely used. Analysis of ventilation showed that median Vt was 7.1 mL/kg PBW (IQR 5.9–9.1) and 21.3% of patients had optimal ventilation during their ICU stay. Conclusions: One in four mechanically ventilated patients have AHRF. Despite advances of care and better, but not optimal, utilisation of low tidal volume ventilation, mortality remains high. |
format | Online Article Text |
id | pubmed-7692809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76928092020-11-28 Prevalence and Outcomes of Acute Hypoxaemic Respiratory Failure in Wales: The PANDORA-WALES Study Kopczynska, Maja Sharif, Ben Pugh, Richard Otahal, Igor Havalda, Peter Groblewski, Wojciech Lynch, Ceri George, David Sutherland, Jayne Pandey, Manish Jones, Phillippa Murdoch, Maxene Hatalyak, Adam Jones, Rhidian Kacmarek, Robert M. Villar, Jesús Szakmany, Tamas J Clin Med Article Background: We aimed to identify the prevalence of acute hypoxaemic respiratory failure (AHRF) in the intensive care unit (ICU) and its associated mortality. The secondary aim was to describe ventilatory management as well as the use of rescue therapies. Methods: Multi-centre prospective study in nine hospitals in Wales, UK, over 2-month periods. All patients admitted to an ICU were screened for AHRF and followed-up until discharge from the ICU. Data were collected from patient charts on patient demographics, clinical characteristics, management and outcomes. Results: Out of 2215 critical care admissions, 886 patients received mechanical ventilation. A total of 197 patients met inclusion criteria and were recruited. Seventy (35.5%) were non-survivors. Non-survivors were significantly older, had higher SOFA scores and received more vasopressor support than survivors. Twenty-five (12.7%) patients who fulfilled the Berlin definition of acute respiratory distress syndrome (ARDS) during the ICU stay without impact on overall survival. Rescue therapies were rarely used. Analysis of ventilation showed that median Vt was 7.1 mL/kg PBW (IQR 5.9–9.1) and 21.3% of patients had optimal ventilation during their ICU stay. Conclusions: One in four mechanically ventilated patients have AHRF. Despite advances of care and better, but not optimal, utilisation of low tidal volume ventilation, mortality remains high. MDPI 2020-10-31 /pmc/articles/PMC7692809/ /pubmed/33142837 http://dx.doi.org/10.3390/jcm9113521 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kopczynska, Maja Sharif, Ben Pugh, Richard Otahal, Igor Havalda, Peter Groblewski, Wojciech Lynch, Ceri George, David Sutherland, Jayne Pandey, Manish Jones, Phillippa Murdoch, Maxene Hatalyak, Adam Jones, Rhidian Kacmarek, Robert M. Villar, Jesús Szakmany, Tamas Prevalence and Outcomes of Acute Hypoxaemic Respiratory Failure in Wales: The PANDORA-WALES Study |
title | Prevalence and Outcomes of Acute Hypoxaemic Respiratory Failure in Wales: The PANDORA-WALES Study |
title_full | Prevalence and Outcomes of Acute Hypoxaemic Respiratory Failure in Wales: The PANDORA-WALES Study |
title_fullStr | Prevalence and Outcomes of Acute Hypoxaemic Respiratory Failure in Wales: The PANDORA-WALES Study |
title_full_unstemmed | Prevalence and Outcomes of Acute Hypoxaemic Respiratory Failure in Wales: The PANDORA-WALES Study |
title_short | Prevalence and Outcomes of Acute Hypoxaemic Respiratory Failure in Wales: The PANDORA-WALES Study |
title_sort | prevalence and outcomes of acute hypoxaemic respiratory failure in wales: the pandora-wales study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692809/ https://www.ncbi.nlm.nih.gov/pubmed/33142837 http://dx.doi.org/10.3390/jcm9113521 |
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