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Membrane Microreactors for the On‐Demand Generation, Separation, and Reaction of Gases
The use of gases as reagents in organic synthesis can be very challenging, particularly at a laboratory scale. This Concept takes into account recent studies to make the case that gases can indeed be efficiently and safely formed from relatively inexpensive commercially available reagents for use in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692882/ https://www.ncbi.nlm.nih.gov/pubmed/32515835 http://dx.doi.org/10.1002/chem.202001942 |
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author | Hone, Christopher A. Kappe, C. Oliver |
author_facet | Hone, Christopher A. Kappe, C. Oliver |
author_sort | Hone, Christopher A. |
collection | PubMed |
description | The use of gases as reagents in organic synthesis can be very challenging, particularly at a laboratory scale. This Concept takes into account recent studies to make the case that gases can indeed be efficiently and safely formed from relatively inexpensive commercially available reagents for use in a wide range of organic transformations. In particular, we argue that the exploitation of continuous flow membrane reactors enables the effective separation of the chemistry necessary for gas formation from the chemistry for gas consumption, with these two stages often containing incompatible chemistry. The approach outlined eliminates the need to store and transport excessive amounts of potentially toxic, reactive or explosive gases. The on‐demand generation, separation and reaction of a number of gases, including carbon monoxide, diazomethane, trifluoromethyl diazomethane, hydrogen cyanide, ammonia and formaldehyde, is discussed. |
format | Online Article Text |
id | pubmed-7692882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76928822020-12-08 Membrane Microreactors for the On‐Demand Generation, Separation, and Reaction of Gases Hone, Christopher A. Kappe, C. Oliver Chemistry Concepts The use of gases as reagents in organic synthesis can be very challenging, particularly at a laboratory scale. This Concept takes into account recent studies to make the case that gases can indeed be efficiently and safely formed from relatively inexpensive commercially available reagents for use in a wide range of organic transformations. In particular, we argue that the exploitation of continuous flow membrane reactors enables the effective separation of the chemistry necessary for gas formation from the chemistry for gas consumption, with these two stages often containing incompatible chemistry. The approach outlined eliminates the need to store and transport excessive amounts of potentially toxic, reactive or explosive gases. The on‐demand generation, separation and reaction of a number of gases, including carbon monoxide, diazomethane, trifluoromethyl diazomethane, hydrogen cyanide, ammonia and formaldehyde, is discussed. John Wiley and Sons Inc. 2020-09-11 2020-10-15 /pmc/articles/PMC7692882/ /pubmed/32515835 http://dx.doi.org/10.1002/chem.202001942 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Concepts Hone, Christopher A. Kappe, C. Oliver Membrane Microreactors for the On‐Demand Generation, Separation, and Reaction of Gases |
title | Membrane Microreactors for the On‐Demand Generation, Separation, and Reaction of Gases |
title_full | Membrane Microreactors for the On‐Demand Generation, Separation, and Reaction of Gases |
title_fullStr | Membrane Microreactors for the On‐Demand Generation, Separation, and Reaction of Gases |
title_full_unstemmed | Membrane Microreactors for the On‐Demand Generation, Separation, and Reaction of Gases |
title_short | Membrane Microreactors for the On‐Demand Generation, Separation, and Reaction of Gases |
title_sort | membrane microreactors for the on‐demand generation, separation, and reaction of gases |
topic | Concepts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692882/ https://www.ncbi.nlm.nih.gov/pubmed/32515835 http://dx.doi.org/10.1002/chem.202001942 |
work_keys_str_mv | AT honechristophera membranemicroreactorsfortheondemandgenerationseparationandreactionofgases AT kappecoliver membranemicroreactorsfortheondemandgenerationseparationandreactionofgases |