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Diversely Functionalised Cytochalasins through Mutasynthesis and Semi‐Synthesis
Mutasynthesis of pyrichalasin H from Magnaporthe grisea NI980 yielded a series of unprecedented 4′‐substituted cytochalasin analogues in titres as high as the wild‐type system (≈60 mg L(−1)). Halogenated, O‐alkyl, O‐allyl and O‐propargyl examples were formed, as well as a 4′‐azido analogue. 4′‐O‐Pro...
Autores principales: | Wang, Chongqing, Lambert, Christopher, Hauser, Maurice, Deuschmann, Adrian, Zeilinger, Carsten, Rottner, Klemens, Stradal, Theresia E. B., Stadler, Marc, Skellam, Elizabeth J., Cox, Russell J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692911/ https://www.ncbi.nlm.nih.gov/pubmed/32484589 http://dx.doi.org/10.1002/chem.202002241 |
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