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Changing patterns in the epidemiology of β‐thalassemia
β‐thalassemia major is an inherited hemoglobinopathy that requires lifelong red blood cell transfusions and iron chelation therapy to prevent complications due to iron overload. Traditionally, β‐thalassemia has been more common in certain regions of the world such as the Mediterranean, Middle East,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692954/ https://www.ncbi.nlm.nih.gov/pubmed/32886826 http://dx.doi.org/10.1111/ejh.13512 |
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author | Kattamis, Antonis Forni, Gian Luca Aydinok, Yesim Viprakasit, Vip |
author_facet | Kattamis, Antonis Forni, Gian Luca Aydinok, Yesim Viprakasit, Vip |
author_sort | Kattamis, Antonis |
collection | PubMed |
description | β‐thalassemia major is an inherited hemoglobinopathy that requires lifelong red blood cell transfusions and iron chelation therapy to prevent complications due to iron overload. Traditionally, β‐thalassemia has been more common in certain regions of the world such as the Mediterranean, Middle East, and Southeast Asia. However, the prevalence of β‐thalassemia is increasing in other regions, including Northern Europe and North America, primarily due to migration. This review summarizes the available data on the changing incidence and prevalence of β‐thalassemia as well as factors influencing disease frequency. The data suggest that the epidemiology of β‐thalassemia is changing: Migration has increased the prevalence of the disease in regions traditionally believed to have a low prevalence, while, at the same time, prevention and screening programs in endemic regions have reduced the number of affected individuals. Various approaches to prevention and screening have been used. Region‐specific prevention and treatment programs, customized to align with local healthcare resources and cultural values, have been effective in identifying patients and carriers and providing information and care. Significant challenges remain in universally implementing these programs. |
format | Online Article Text |
id | pubmed-7692954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76929542020-12-08 Changing patterns in the epidemiology of β‐thalassemia Kattamis, Antonis Forni, Gian Luca Aydinok, Yesim Viprakasit, Vip Eur J Haematol Review Articles β‐thalassemia major is an inherited hemoglobinopathy that requires lifelong red blood cell transfusions and iron chelation therapy to prevent complications due to iron overload. Traditionally, β‐thalassemia has been more common in certain regions of the world such as the Mediterranean, Middle East, and Southeast Asia. However, the prevalence of β‐thalassemia is increasing in other regions, including Northern Europe and North America, primarily due to migration. This review summarizes the available data on the changing incidence and prevalence of β‐thalassemia as well as factors influencing disease frequency. The data suggest that the epidemiology of β‐thalassemia is changing: Migration has increased the prevalence of the disease in regions traditionally believed to have a low prevalence, while, at the same time, prevention and screening programs in endemic regions have reduced the number of affected individuals. Various approaches to prevention and screening have been used. Region‐specific prevention and treatment programs, customized to align with local healthcare resources and cultural values, have been effective in identifying patients and carriers and providing information and care. Significant challenges remain in universally implementing these programs. John Wiley and Sons Inc. 2020-09-21 2020-12 /pmc/articles/PMC7692954/ /pubmed/32886826 http://dx.doi.org/10.1111/ejh.13512 Text en © 2020 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Kattamis, Antonis Forni, Gian Luca Aydinok, Yesim Viprakasit, Vip Changing patterns in the epidemiology of β‐thalassemia |
title | Changing patterns in the epidemiology of β‐thalassemia |
title_full | Changing patterns in the epidemiology of β‐thalassemia |
title_fullStr | Changing patterns in the epidemiology of β‐thalassemia |
title_full_unstemmed | Changing patterns in the epidemiology of β‐thalassemia |
title_short | Changing patterns in the epidemiology of β‐thalassemia |
title_sort | changing patterns in the epidemiology of β‐thalassemia |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692954/ https://www.ncbi.nlm.nih.gov/pubmed/32886826 http://dx.doi.org/10.1111/ejh.13512 |
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