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Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma

Several air pollution components such as sulfur dioxide, ozone, nitrogen dioxide, and diesel exhaust particulate matter (DEPM) have been linked to the development of asthma. In this study, we investigated the therapeutic potential of three lactic acid bacteria species, Lactobacillus plantarum GREEN...

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Autores principales: Jin, Sun Woo, Lee, Gi Ho, Jang, Min Jung, Hong, Gyeong Eun, Kim, Jae Young, Park, Gi Deok, Jin, Hui, Kim, Hyun Su, Choi, Chul Yung, Choi, Jae Ho, Lee, Su Gwon, Jeong, Hye Gwang, Hwang, Yong Pil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692958/
https://www.ncbi.nlm.nih.gov/pubmed/33126646
http://dx.doi.org/10.3390/life10110260
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author Jin, Sun Woo
Lee, Gi Ho
Jang, Min Jung
Hong, Gyeong Eun
Kim, Jae Young
Park, Gi Deok
Jin, Hui
Kim, Hyun Su
Choi, Chul Yung
Choi, Jae Ho
Lee, Su Gwon
Jeong, Hye Gwang
Hwang, Yong Pil
author_facet Jin, Sun Woo
Lee, Gi Ho
Jang, Min Jung
Hong, Gyeong Eun
Kim, Jae Young
Park, Gi Deok
Jin, Hui
Kim, Hyun Su
Choi, Chul Yung
Choi, Jae Ho
Lee, Su Gwon
Jeong, Hye Gwang
Hwang, Yong Pil
author_sort Jin, Sun Woo
collection PubMed
description Several air pollution components such as sulfur dioxide, ozone, nitrogen dioxide, and diesel exhaust particulate matter (DEPM) have been linked to the development of asthma. In this study, we investigated the therapeutic potential of three lactic acid bacteria species, Lactobacillus plantarum GREEN CROSS Wellbeing (GCWB)1001, Pediococcus acidilactici GCWB1085, and Lactobacillus rhamnosus GCWB1156, in preventing DEPM-exacerbated asthma in mice. BALB/c mice were first sensitized with ovalbumin (OVA) and were either challenged with OVA or DEPM (DEPM-exacerbated asthma model) by intranasal instillation. All three strains showed no hemolytic activity, suggesting a good safety profile. Oral administration of lactic acid bacteria reduced OVA + DEPM-induced inflammatory infiltration, goblet cell hyperplasia, airway remodeling, and the levels of proinflammatory cytokines and chemokines in bronchoalveolar lavage fluid (BALF). The probiotics also attenuated OVA + DEPM-induced immunoglobulin E (IgE) levels in serum and in BALF, and significantly reduced caspase-3 activity, total collagen level, and matrix metalloproteinase (MMP)-9 activity. In conclusion, lactic acid bacteria such as L. plantarum GCWB1001, P. acidilactici GCWB1085, and L. rhamnosus treatment in mice with asthma showed significant efficacy in preventing lung inflammation exacerbated by DEPM administration.
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spelling pubmed-76929582020-11-28 Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma Jin, Sun Woo Lee, Gi Ho Jang, Min Jung Hong, Gyeong Eun Kim, Jae Young Park, Gi Deok Jin, Hui Kim, Hyun Su Choi, Chul Yung Choi, Jae Ho Lee, Su Gwon Jeong, Hye Gwang Hwang, Yong Pil Life (Basel) Article Several air pollution components such as sulfur dioxide, ozone, nitrogen dioxide, and diesel exhaust particulate matter (DEPM) have been linked to the development of asthma. In this study, we investigated the therapeutic potential of three lactic acid bacteria species, Lactobacillus plantarum GREEN CROSS Wellbeing (GCWB)1001, Pediococcus acidilactici GCWB1085, and Lactobacillus rhamnosus GCWB1156, in preventing DEPM-exacerbated asthma in mice. BALB/c mice were first sensitized with ovalbumin (OVA) and were either challenged with OVA or DEPM (DEPM-exacerbated asthma model) by intranasal instillation. All three strains showed no hemolytic activity, suggesting a good safety profile. Oral administration of lactic acid bacteria reduced OVA + DEPM-induced inflammatory infiltration, goblet cell hyperplasia, airway remodeling, and the levels of proinflammatory cytokines and chemokines in bronchoalveolar lavage fluid (BALF). The probiotics also attenuated OVA + DEPM-induced immunoglobulin E (IgE) levels in serum and in BALF, and significantly reduced caspase-3 activity, total collagen level, and matrix metalloproteinase (MMP)-9 activity. In conclusion, lactic acid bacteria such as L. plantarum GCWB1001, P. acidilactici GCWB1085, and L. rhamnosus treatment in mice with asthma showed significant efficacy in preventing lung inflammation exacerbated by DEPM administration. MDPI 2020-10-28 /pmc/articles/PMC7692958/ /pubmed/33126646 http://dx.doi.org/10.3390/life10110260 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jin, Sun Woo
Lee, Gi Ho
Jang, Min Jung
Hong, Gyeong Eun
Kim, Jae Young
Park, Gi Deok
Jin, Hui
Kim, Hyun Su
Choi, Chul Yung
Choi, Jae Ho
Lee, Su Gwon
Jeong, Hye Gwang
Hwang, Yong Pil
Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma
title Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma
title_full Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma
title_fullStr Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma
title_full_unstemmed Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma
title_short Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma
title_sort lactic acid bacteria ameliorate diesel exhaust particulate matter-exacerbated allergic inflammation in a murine model of asthma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692958/
https://www.ncbi.nlm.nih.gov/pubmed/33126646
http://dx.doi.org/10.3390/life10110260
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