A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors

A versatile one‐step photopolymerization approach for the immobilization of enantioselective organocatalysts is presented. Chiral organocatalyst‐containing monoliths based on polystyrene divinylbenzene copolymer were generated inside channels of microfluidic chips. Exemplary performance tests were p...

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Detalles Bibliográficos
Autores principales: Warias, Rico, Ragno, Daniele, Massi, Alessandro, Belder, Detlev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693110/
https://www.ncbi.nlm.nih.gov/pubmed/32453458
http://dx.doi.org/10.1002/chem.202002063
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author Warias, Rico
Ragno, Daniele
Massi, Alessandro
Belder, Detlev
author_facet Warias, Rico
Ragno, Daniele
Massi, Alessandro
Belder, Detlev
author_sort Warias, Rico
collection PubMed
description A versatile one‐step photopolymerization approach for the immobilization of enantioselective organocatalysts is presented. Chiral organocatalyst‐containing monoliths based on polystyrene divinylbenzene copolymer were generated inside channels of microfluidic chips. Exemplary performance tests were performed for the monolithic Hayashi–Jørgensen catalyst in continuous flow, which showed good results for the Michael addition of aldehydes to nitroalkenes in terms of stereoselectivity and catalyst stability with minimal consumption of reagents and solvents.
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spelling pubmed-76931102020-12-11 A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors Warias, Rico Ragno, Daniele Massi, Alessandro Belder, Detlev Chemistry Communications A versatile one‐step photopolymerization approach for the immobilization of enantioselective organocatalysts is presented. Chiral organocatalyst‐containing monoliths based on polystyrene divinylbenzene copolymer were generated inside channels of microfluidic chips. Exemplary performance tests were performed for the monolithic Hayashi–Jørgensen catalyst in continuous flow, which showed good results for the Michael addition of aldehydes to nitroalkenes in terms of stereoselectivity and catalyst stability with minimal consumption of reagents and solvents. John Wiley and Sons Inc. 2020-09-17 2020-10-15 /pmc/articles/PMC7693110/ /pubmed/32453458 http://dx.doi.org/10.1002/chem.202002063 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Warias, Rico
Ragno, Daniele
Massi, Alessandro
Belder, Detlev
A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors
title A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors
title_full A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors
title_fullStr A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors
title_full_unstemmed A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors
title_short A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors
title_sort visible‐light‐powered polymerization method for the immobilization of enantioselective organocatalysts into microreactors
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693110/
https://www.ncbi.nlm.nih.gov/pubmed/32453458
http://dx.doi.org/10.1002/chem.202002063
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