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A Review of Nephrotoxicity of Microcystins
Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies h...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693154/ https://www.ncbi.nlm.nih.gov/pubmed/33142924 http://dx.doi.org/10.3390/toxins12110693 |
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author | Xu, Shuaishuai Yi, Xiping Liu, Wenya Zhang, Chengcheng Massey, Isaac Yaw Yang, Fei Tian, Li |
author_facet | Xu, Shuaishuai Yi, Xiping Liu, Wenya Zhang, Chengcheng Massey, Isaac Yaw Yang, Fei Tian, Li |
author_sort | Xu, Shuaishuai |
collection | PubMed |
description | Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies have suggested that aside liver, the kidney may be another target organ of MCs intoxication. Therefore, this review provides various evidences on the nephrotoxicity of MCs. The review concludes that nephrotoxicity of MCs may be related to inhibition of protein phosphatases and excessive production of reactive oxygen species, cytoskeleton disruption, endoplasmic reticulum stress, DNA damage and cell apoptosis. To protect human from MCs toxic consequences, this paper also puts forward some directions for further research. |
format | Online Article Text |
id | pubmed-7693154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76931542020-11-28 A Review of Nephrotoxicity of Microcystins Xu, Shuaishuai Yi, Xiping Liu, Wenya Zhang, Chengcheng Massey, Isaac Yaw Yang, Fei Tian, Li Toxins (Basel) Review Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies have suggested that aside liver, the kidney may be another target organ of MCs intoxication. Therefore, this review provides various evidences on the nephrotoxicity of MCs. The review concludes that nephrotoxicity of MCs may be related to inhibition of protein phosphatases and excessive production of reactive oxygen species, cytoskeleton disruption, endoplasmic reticulum stress, DNA damage and cell apoptosis. To protect human from MCs toxic consequences, this paper also puts forward some directions for further research. MDPI 2020-10-31 /pmc/articles/PMC7693154/ /pubmed/33142924 http://dx.doi.org/10.3390/toxins12110693 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xu, Shuaishuai Yi, Xiping Liu, Wenya Zhang, Chengcheng Massey, Isaac Yaw Yang, Fei Tian, Li A Review of Nephrotoxicity of Microcystins |
title | A Review of Nephrotoxicity of Microcystins |
title_full | A Review of Nephrotoxicity of Microcystins |
title_fullStr | A Review of Nephrotoxicity of Microcystins |
title_full_unstemmed | A Review of Nephrotoxicity of Microcystins |
title_short | A Review of Nephrotoxicity of Microcystins |
title_sort | review of nephrotoxicity of microcystins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693154/ https://www.ncbi.nlm.nih.gov/pubmed/33142924 http://dx.doi.org/10.3390/toxins12110693 |
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