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A Review of Nephrotoxicity of Microcystins

Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies h...

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Autores principales: Xu, Shuaishuai, Yi, Xiping, Liu, Wenya, Zhang, Chengcheng, Massey, Isaac Yaw, Yang, Fei, Tian, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693154/
https://www.ncbi.nlm.nih.gov/pubmed/33142924
http://dx.doi.org/10.3390/toxins12110693
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author Xu, Shuaishuai
Yi, Xiping
Liu, Wenya
Zhang, Chengcheng
Massey, Isaac Yaw
Yang, Fei
Tian, Li
author_facet Xu, Shuaishuai
Yi, Xiping
Liu, Wenya
Zhang, Chengcheng
Massey, Isaac Yaw
Yang, Fei
Tian, Li
author_sort Xu, Shuaishuai
collection PubMed
description Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies have suggested that aside liver, the kidney may be another target organ of MCs intoxication. Therefore, this review provides various evidences on the nephrotoxicity of MCs. The review concludes that nephrotoxicity of MCs may be related to inhibition of protein phosphatases and excessive production of reactive oxygen species, cytoskeleton disruption, endoplasmic reticulum stress, DNA damage and cell apoptosis. To protect human from MCs toxic consequences, this paper also puts forward some directions for further research.
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spelling pubmed-76931542020-11-28 A Review of Nephrotoxicity of Microcystins Xu, Shuaishuai Yi, Xiping Liu, Wenya Zhang, Chengcheng Massey, Isaac Yaw Yang, Fei Tian, Li Toxins (Basel) Review Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies have suggested that aside liver, the kidney may be another target organ of MCs intoxication. Therefore, this review provides various evidences on the nephrotoxicity of MCs. The review concludes that nephrotoxicity of MCs may be related to inhibition of protein phosphatases and excessive production of reactive oxygen species, cytoskeleton disruption, endoplasmic reticulum stress, DNA damage and cell apoptosis. To protect human from MCs toxic consequences, this paper also puts forward some directions for further research. MDPI 2020-10-31 /pmc/articles/PMC7693154/ /pubmed/33142924 http://dx.doi.org/10.3390/toxins12110693 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Shuaishuai
Yi, Xiping
Liu, Wenya
Zhang, Chengcheng
Massey, Isaac Yaw
Yang, Fei
Tian, Li
A Review of Nephrotoxicity of Microcystins
title A Review of Nephrotoxicity of Microcystins
title_full A Review of Nephrotoxicity of Microcystins
title_fullStr A Review of Nephrotoxicity of Microcystins
title_full_unstemmed A Review of Nephrotoxicity of Microcystins
title_short A Review of Nephrotoxicity of Microcystins
title_sort review of nephrotoxicity of microcystins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693154/
https://www.ncbi.nlm.nih.gov/pubmed/33142924
http://dx.doi.org/10.3390/toxins12110693
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